The EMPOWER Study: Endometriosis Diagnosis Using MicroRNA

Inclusion Criteria:

1. Participant is willing and able to provide written informed consent.

2. Participant is willing and able to provide up to 50 mL of blood via venipuncture andcomply with all other study and sample collection procedures.

3. Participant is a female aged 18 through 49 years (inclusive).

4. Participant is scheduled to undergo:

5. Laparotomy or laparoscopy for signs and symptoms of suspected endometriosis.This shall constitute approximately 95% of the participants enrolled.

6. Laparotomy, laparoscopy, or other procedures including, but not limited to,tubal ligation, lysis of adhesions, hysterectomy for benign condition,myomectomy, salpingo-oophorectomy, cystectomy, or diagnostic laparoscopy forindications including, but not limited to, infertility or benign gynecologicalindications (e.g., benign pelvic masses, infertility, abnormal uterinebleeding). This shall constitute approximately 5% of the participants enrolled.

Exclusion Criteria:

1. Participant has a history of surgically determined diagnosis of endometriosis (either via visual inspection or histopathology).

2. Participant is a female in a pre-menarchal or post-menopausal state (last menstrualperiod at least 1 year before Screening and no other biological or physiologicalcause can be identified) or has been rendered surgically menopausal (bilateraloophorectomy) for at least 6 months at Screening.

3. Participant is pregnant.

4. Participant has an active malignancy.

5. Participant is known to have tested positive for human immunodeficiency virus orhepatitis A, B, or C.

6. Participant has an active pelvic infection or other infections contraindicated forsurgery.

7. Participant has participated (±3 months of study enrollment) in a clinical trialwhere an investigational drug was or is planned to be administered.

8. Participant has any general health or behavioral condition that, in the opinion ofthe investigator, should exclude the participant from participation.