Comparison of the Effectiveness of Two Psycho-physical Interventions: Mindfulness Based Relapse Prevention (MBRP) and Unguided Meditative Relaxation in Patients with Alcohol Use Disorder

Last updated: February 11, 2025
Sponsor: Centre Hospitalier Universitaire de Nīmes
Overall Status: Active - Recruiting

Phase

N/A

Condition

Substance Abuse

Alcohol Dependence

Alcohol Use Disorder

Treatment

Relaxation/ meditation

Mindfulness Based Relapse Prevention

Clinical Study ID

NCT04598399
PHRCN/2018/AL-01
  • Ages > 18
  • All Genders

Study Summary

Alcohol use disorder (AUD) is the second highest preventable cause of death in France. Only 3% of patients are prescribed approved drugs for reducing alcohol consumption or maintenance of abstinence. Increasing evidence supports the efficacy of psychotherapies such as cognitive and behavioral therapies (CBT) in AUD. However, some patients are resistant to CBT and the positive effects of CBT could wane over time, resulting in mid- and long-term relapses. Mindfulness practice is increasingly widespread in the United States and its efficacy in various fields appears very promising. The study investigators hypothesize that the Mindfulness Based Relapse Prevention (MBRP) program will be more efficient than a relaxation/meditation without guidance control program in AUD.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Having a moderate to severe alcohol use disorder according to DSM 5 criteria.

  • The last drink must have been consumed at most in the last 60 days before thepre-inclusion visit. The patient must have had at least 1 HDD during the lastdrinking period

Exclusion

Exclusion Criteria:

  • Severe depression (Beck Depression Inventory> 30)

  • Schizophrenic disorder,

  • Current maniac or hypomaniac episode,

  • Patient with dementia or severe cognitive impairment that would prevent him/her fromfollowing the course of a session, as judged by the clinician.

  • Insufficient French understanding to complete the questionnaires

  • Pregnant or breastfeeding woman

  • Absence of social security regimen

  • Other mindfulness-based structured therapies

  • Refusal to sign the written consent. • The patient is under safeguard of justice orstate guardianship

Study Design

Total Participants: 168
Treatment Group(s): 2
Primary Treatment: Relaxation/ meditation
Phase:
Study Start date:
October 20, 2021
Estimated Completion Date:
November 30, 2025

Connect with a study center

  • Ssra Les Eumenides

    Angers, 49100
    France

    Active - Recruiting

  • Hôpital Corentin-Celton

    Issy-les-Moulineaux,
    France

    Site Not Available

  • CHU de Nantes

    Nantes,
    France

    Active - Recruiting

  • CHU de Nimes

    Nîmes,
    France

    Active - Recruiting

  • Hopital Fernand Widal

    Paris, 75010
    France

    Site Not Available

  • Le CSAPA - Association Charonne

    Paris,
    France

    Site Not Available

  • Hopital Des 4 Villes

    Sèvres, 92310
    France

    Site Not Available

  • Hopital Paul Brousse

    Villejuif,
    France

    Site Not Available

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