Phase
Condition
Low Blood Pressure (Hypotension)
Sepsis And Septicemia
Renal Failure
Treatment
placebo treatment
Nicotinamide treatment
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Adult patients with septic shock defined as sepsis with persisting hypotensionrequiring vasopressors to maintain MAP ≥65 mm Hg and having a serum lactate level >2mmol/L (18 mg/dL) despite adequate volume resuscitation.
Written informed consent
Exclusion
Exclusion Criteria:
Presence of inclusion criteria for more than 24 hours
Immediate indication to start renal replacement therapy at the time ofrandomization: Hyperkalemia≥ 6.5 mmol /l, metabolic acidosis with pH <7.15 notcontrolled by medical treatment, diuretic resistant acute pulmonary edema oraccumulation of a toxic requiring dialysis.
Formal indication of Nicotinamide supplementation according to the attendingphysician (eg pellagra, undernutrition, severe alcoholism)
Known severe chronic kidney disease (clearance <30 ml /min) in the last 3 monthspreceding the setic shock or kidney transplant recipient.
Moribund patient (estimated survival less than 24 hours)
Patient who are not expected to survive to day 30 due to terminal-stage disease (terminal respiratory or heart failure, Child C cirrhosis, uncontrolled cancer)
Resuscitated cardiac arrest
Pregnant or lactating
Legal tutorship and guardianship
Lack of social security coverage.
Study Design
Connect with a study center
CHU Amiens
Amiens, 80480
FranceActive - Recruiting
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