Researching the Effect of Exercise on Cancer

Inclusion Criteria:

• Postsurgical diagnosis of patients with primary solid tumors at high-risk of relapseas defined by one of the following:

° High-risk primary solid tumor (e.g., colorectal, ovarian, non-small cell lungcancer) (colorectal cancer only for Phase 1a)

• Stage 3 or

• ctDNA positive

° High-risk breast cancer

• Residual invasive disease in the breast or the lymph nodes following completion ofneoadjuvant chemotherapy (NACT),

• Estrogen receptor (ER), and/or progesterone receptor (PR) positive and HER2negative,

• CPS-EG score ≥ 3,

• CPS-EG score ≥2 w ith ypN+, or

• Recurrence score ≥ 25

• No evidence of disease

• Age ≥ 18

• Interval of ≥ 1 month but ≤ 2 years following completion of all definitive adjuvanttherapy

• Non-exercising (i.e., < 30 minutes of moderate and < 20 mins of vigorousexercise/wk), as assessed by remote activity and heart rate tracking for a 7-dayperiod prior to study entry)

° If ≥ 30 minutes but less than 45 minutes of moderate exercise/week, or if ≥ 20minutes but less than 30 minutes of vigorous exercise/week, patients may beeligible, at the discretion of the PI.

• Cleared for exercise participation as per screening clearance via PAR-Q+

• Willingness to comply with all study-related procedures

Exclusion Criteria:

• Enrollment onto any other interventional investigational study except interventionsdetermined by the PI not to confound study outcomes

• Any other current diagnosis of invasive cancer of any kind

• Distant metastatic malignancy of any kind

• Any other condition or intercurrent illness that, in the opinion of theinvestigator, makes the subject a poor candidate for study participation