Effect of Collagen Supplementation on Tendinopathy

Last updated: November 1, 2024
Sponsor: Bispebjerg Hospital
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Sprains

Tendon Injuries

Treatment

Placebo

Hydrolyzed collagen

Heavy slow resistance training

Clinical Study ID

NCT04578418
H-16019857
  • Ages 18-40
  • All Genders

Study Summary

Tendon injuries represent a significant problem in elite athletes. Therefore, prevention and effective treatment of tendon overload injury/tendinopathy is important. Among different treatment options, heavy-slow loading based rehabilitation is considered among the most efficient treatments in athletes. In this study, we will investigate if supplementation with hydrolyzed collagen in combination with a heavy-slow loading based 12 weeks rehabilitation regime can improve treatment of tendon overload injury/tendinopathy. The investigators will examine elite athletes with overload injury/tendinopathy with regards to symptoms (pain, function), tendon morphology (ultrasonography), and vascularization (Doppler US). The investigators hypothesize that collagen supplementation can have an improving effect on tendon pain and function. Thus, the investigation will show if a rehabilitation regime of collagen supplementation combined with heavy-slow mechanical loading can improve tendon healing compared to mechanical loading alone.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Elite athletes

  • 18-40 years old

  • Exercise related tendon pain on one or both legs

  • Soreness during physical examination of tendon upon palpation

  • Uni- or bilateral tendinopathy symptoms > 3 months

Exclusion

Exclusion Criteria:

  • Previous tendon surgery

  • Diabetes

  • Arthritis

  • Corticosteroid injection for tendinopathy within the last 3 months

  • Any form of tendon injection within the last 3 months

  • Smoking

Study Design

Total Participants: 64
Treatment Group(s): 3
Primary Treatment: Placebo
Phase:
Study Start date:
September 16, 2020
Estimated Completion Date:
May 01, 2025

Study Description

Randomized placebo-controlled intervention study with follow-up after one month

Connect with a study center

  • Department of Physical and Occupational Therapy/Institute of Sports Medicine Copenhagen, Bispebjerg Hospital

    Copenhagen NV, 2400
    Denmark

    Site Not Available

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