The Ability of Adipose Flap Over the NVB to Improve Sexual and Urinary Function Following Radical Prostatectomy

Last updated: October 5, 2020
Sponsor: Rabin Medical Center
Overall Status: Active - Recruiting

Phase

N/A

Condition

Urinary Incontinence

Prostate Cancer

Enuresis

Treatment

N/A

Clinical Study ID

NCT04577222
212-18
  • Male

Study Summary

Despite technological advances, incontinence and impotence remain significant side effects of radical prostatectomy (RP). Strategies have been developed to reduce the injury to the erection nerves (i.e. neurovascular bundle - NVB)during surgery to further improve functional outcomes after RP. Adipose tissue is known for its stabilizing and even healing potential. These features include reducing the inflammatory process and improving blood supply to an injured nerve. We hypothesized that covering the NVB with periprostatic fat during surgery may potentially improve neural recovery and enhance functional recovery after RP. We sought to examine our hypothesis in a randomized controlled trial.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Male aged 18 years and older.

  2. Patients diagnosed with prostate cancer.

  3. Patients should be potent (IIEF erectile function domain score of 26 and above) andhave a sexual partner.

  4. Patients scheduled for Radical Prostatectomy with NVB preservation (at leastunilateral).

Exclusion

Exclusion Criteria: Patients who did not undergo NVB preservation or technical inability to create flap

Study Design

Total Participants: 60
Study Start date:
April 15, 2018
Estimated Completion Date:
July 15, 2022

Connect with a study center

  • Rabin Medical Center

    Petach Tikva,
    Israel

    Active - Recruiting

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