Effect of Anthracyclines and Cyclophosphamide on Cardiovascular Responses

Last updated: March 28, 2025
Sponsor: University of Sao Paulo General Hospital
Overall Status: Completed

Phase

N/A

Condition

Diabetes Prevention

Breast Cancer

Vascular Diseases

Treatment

Endothelium-dependent vascular function

Muscular Sympathetic Nervous Activity

Cardiac Function

Clinical Study ID

NCT04568161
Breast Cancer Chemotherapy
  • Ages 45-60
  • Female

Study Summary

The present study aims to investigate the chronic effect of treatment with doxorubicin and cyclophosphamide on neurovascular control and blood pressure in women undergoing adjuvant treatment for breast cancer.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • diagnosis of stage II-III breast cancer

  • starting adjuvant chemotherapy

Exclusion

Exclusion Criteria:

  • metastatic disease,

  • hypercholesterolemia, diabetes,

  • hypertension,

  • severe lymphedema,

  • organic disorders (renal failure, heart failure and chronic liver disease),

  • obesity (BMI> 30) and,

  • who are under pharmacological treatment with statins, angiotensin-converting enzymeinhibitors, losartan potassium, beta blockers or antioxidants

Study Design

Total Participants: 15
Treatment Group(s): 11
Primary Treatment: Endothelium-dependent vascular function
Phase:
Study Start date:
August 03, 2020
Estimated Completion Date:
March 03, 2025

Study Description

The development of new drugs and different adjuvant therapeutic regimens, based on the combination of anthracycline (A) and cyclophosphamide (C), have contributed greatly to improve survival rate in breast cancer patients. Despite the clinical benefits of this therapy, AC treatment can cause cardiovascular acute and chronic changes. In a recent investigation, we observed that an acute AC chemotherapy session increases sympathetic nervous activity and blood pressure in patients with breast cancer.

The present study aims to investigate the chronic effects of AC regimen on sympathetic nervous activity, peripheral vasoconstriction, endothelial microparticles and blood pressure, in women with breast cancer.

Connect with a study center

  • Instituto do Coracao (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo

    Sao Paulo, 05403-900
    Brazil

    Site Not Available

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