Gender Differences and SNPs in Asthmatic Patients

Last updated: November 20, 2020
Sponsor: University of Catanzaro
Overall Status: Active - Recruiting

Phase

N/A

Condition

Allergy (Pediatric)

Asthma

Treatment

N/A

Clinical Study ID

NCT04567212
SNPS asthma
  • Ages 6-75
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The GINA 2020 guidelines suggest that asthma affects approximately 300 million persons worldwide. Even if there is a specific drug treatment for each stage of disease (From mild to severe) in some patients it is not efficacy and it culd be reated to the gender difference Polymorphisms seems to be involved in asthma (allergic or not) even if no data have been published concerning the role of gender in this clinical manifestation. The aim of this study is to assess whether genetic variations involved in the genes encoding the two key leukotriene enzymes, ALOX5 and LTC4S, and CysLTR1 are implicated in the sex difference of allergic asthma in a well-characterized patient cohort.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • asthma (allergic or not) diagnosed according to Global Initiative for Asthmaguidelines (GINA 2020).
  • signed informed consent

Exclusion

Exclusion Criteria:

  • • infectious diseases
  • neurodegenerative diseases
  • autoimmune diseases
  • neoplasms
  • progressive serious medical conditions (such as cancer, AIDS or end-stage renaldisease)
  • alcohol consumption (>3 alcoholic beverages daily)
  • substanceabuse
  • inability to give written informed consent
  • those who will not sign the consent to the processing of personal data

Study Design

Total Participants: 50
Study Start date:
August 01, 2020
Estimated Completion Date:
December 30, 2021

Study Description

The GINA 2020 guidelines suggest that asthma affects approximately 300 million persons worldwide. Even if there is a specific drug treatment for each stage of disease (From mild to severe) in some patients it is not efficacy and it culd be reated to the gender difference Polymorphisms seems to be involved in asthma (allergic or not) even if no data have been published concerning the role of gender in this clinical manifestation. The role of polymorphisms in susceptibility to allergic asthma has been partially investigated but no study has analysed gender subgroups separately, neglecting a their potential predictive role in symptomatological and functional variations in the allergic asthma in both sexes. The aim of this study is to assess whether genetic variations involved in the genes encoding the two key leukotriene enzymes, ALOX5 and LTC4S, and CysLTR1 are implicated in the sex difference of allergic asthma in a well-characterized patient cohort.

Connect with a study center

  • AO Materdomini

    Catanzaro, Italia 88100
    Italy

    Active - Recruiting

  • ASP Catanzaro

    Catanzaro, 88100
    Italy

    Active - Recruiting

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