Phase
Condition
Myasthenia Gravis (Chronic Weakness)
Amyotrophic Lateral Sclerosis (Als)
Treatment
EH301 (Nicotinamide Riboside/Pterostilbene)
Clinical Study ID
Ages > 35 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Arm 1 (newly diagnosed ALS patients)
Have a clinical diagnosis of probable ALS according to the revised El Escorialcriteria.
MR of the brain and cervical spine cannot explain symptoms.
Diagnosed with likely ALS within 6 months from enrolment and treated with Riluzole 50mg x 2
Symptom onset no longer than 2 year prior to inclusion.
ALS-FRC-R of 36 or more (not any item below 2).
Age equal to or greater than 35 years at time of enrollment
Arm 2 (earlier diagnosed ALS patients)
Have a clinical diagnosis of probable ALS according to the revised El Escorialcriteria.
MR of the brain and cervical spine cannot explain symptoms.
Treated with Riluzole 50mg x 2.
Exclusion
Exclusion Criteria:
Dementia, FTD or other neurodegenerative disorder at baseline visit
Any psychiatric disorder that would interfere with compliance in the study.
Use of high dose vitamin B3 supplementation within 30 days of enrollment
Metabolic, neoplastic, or other physically or mentally debilitating disorder atbaseline visit.
Genetically confirmed mitochondrial disease
Patients who become tracheostomized as part of the treatment of ALS
Patients with short expected survival at the discretion of the investigator. Suchcases cannot be expected to follow protocol procedures.
Study Design
Connect with a study center
Haukeland University Hospital
Bergen,
NorwayActive - Recruiting
Vestre Viken HF
Drammen,
NorwayActive - Recruiting
Helse Førde HF
Førde,
NorwayActive - Recruiting
Helse Fonna HF
Haugesund,
NorwayActive - Recruiting
Akershus University Hospital
Lørenskog,
NorwayActive - Recruiting
Oslo University Hospital
Oslo,
NorwayActive - Recruiting
Stavanger University Hospital
Stavanger,
NorwayActive - Recruiting
Universitetssykehuset Nord-Norge
Tromsø,
NorwayActive - Recruiting
St.Olavs Hospital HF
Trondheim,
NorwayActive - Recruiting
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