Effort-based Decision-making and CPAP Adherence

Last updated: November 14, 2025
Sponsor: Istituti Clinici Scientifici Maugeri SpA
Overall Status: Active - Recruiting

Phase

N/A

Condition

Sleep Apnea Syndromes

Treatment

Continuous Positive Airway Pressure (CPAP) treatment

Clinical Study ID

NCT04557293
2425
  • Ages 18-80
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Obstructive sleep apnoea is the most common sleep disorder in general population, and is often associated with cognitive deficit, mood disorders, hypertension, diabetes mellitus, excessive daytime somnolence, nicturia and an increased cardiovascular and metabolic risk. The gold standard of treatment is Continuous Positive Airway Pressure (CPAP), but the adherence is often poor. The aim of our study is to investigate the effort based-decision making in patients with OSA, pre and post CPAP treatment, as a possible cause of poor adherence.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age ≥ 18

  • AHI±15

Exclusion

Exclusion Criteria:

  • BMI ≥ 35 Kg/m2

  • MMSE <24

  • Complex sleep apnoea

  • Sleep disorder

  • Psychiatric disorder

Study Design

Total Participants: 64
Treatment Group(s): 1
Primary Treatment: Continuous Positive Airway Pressure (CPAP) treatment
Phase:
Study Start date:
March 10, 2021
Estimated Completion Date:
April 30, 2026

Study Description

Obstructive sleep apnea is a very common disease in general population (24% males; 9% females), characterized by frequent partial or total upper-airway collapse, intermittent hypoxia, arousal from sleep, change in blood pressure, excessive daytime sleepiness, cardiovascular and metabolic diseases, psychological and cognitive consequences. The gold standard treatment is Continuous Positive Airway Pressure (CPAP), but the adherence is often poor. Poor therapy adherence might be partially explained by executive deficits, decreasing the ability to plan and pursue longsighted behaviors entailing immediate costs/efforts. We investigate the cognitive function, in particular effort based-decision making and the relationship with excessive daytime somnolence and other cognitive function in a group of OSA patients and in control group. We assess cognitive function in OSA patients at the diagnosis moment and after six months of CPAP use.

Connect with a study center

  • ICS Maugeri Pavia

    Pavia, 27100
    Italy

    Site Not Available

  • ICS Maugeri Pavia

    Pavia 3171366, 27100
    Italy

    Active - Recruiting

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