American Lung Association (ALA) Lung Health Cohort

Last updated: March 25, 2025
Sponsor: Johns Hopkins University
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT04543461
IRB00236497
U01HL146408
  • Ages 25-35
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The ALA-LHC is a longitudinal, multi-center cohort study that will enroll approximately 4,000 young adults between the ages of 25-35 who do not have severe lung disease. The overarching objective of the ALA-LHC is to establish a national cohort of young adults for the purpose of defining lung health and developing targets to intercept chronic lung disease at its earliest stages.

Eligibility Criteria

Inclusion

Inclusion Criteria:

1- Age 25-35 years at the time of the baseline examination 2- Able to read and understand English or Spanish 3 -Has a social security number 4- Resident (citizen or non-citizen) of the United States (US) for at least 12 months prior to examination. Note: Individuals who are residents of the US who have temporarily spent time living outside of the US during the last 12 months (e.g., student exchange program, military posting) are eligible for participation.

5- Willing to provide contact information for at least 2 proxies who are likely to know the whereabouts and vital status of the participant

Exclusion

Exclusion Criteria:

  1. Severe asthma, which is defined as any of the following:

  2. Current (i.e. at the time of the visit) GINA Step 4 or higher therapy (mediumdose ICS/LABA or high dose ICS or add-on LAMA; Medium dose = >250 fluticasone,propionate =100 fluticasone furoate, >200 beclomethasone, >400 budesonide, >220mometasone). We will accept low-dose ICS/LABA or medium dose ICS.OR

  3. 3 or more unscheduled healthcare visits (provider/urgent care/ER) for asthma inthe past 12 months OR

  4. One asthma hospitalization in the past 12 months

  5. History of any chronic lung disease other than asthma including but not limited toCOPD, cystic fibrosis, pulmonary fibrosis, pulmonary hypertension

  6. Current pregnancy

  7. History of cancer other than non-melanoma skin cancer

  8. Diagnosed cardiovascular diseases (i.e., congenital heart disease, coronary heartdisease)

  9. Inability to comply with study procedures, including

  10. Inability or unwillingness to provide informed consent

  11. Inability to perform study measurements

  12. Inability to be contacted by phone (via calls and/or text messaging) or email

  13. Any condition in the opinion of the physician that puts the participant at risk byparticipating in the study (e.g., serious respiratory illness requiring antibioticsor steroids or severe fever at the time of the study visit).

  14. Institutionalization

Study Design

Total Participants: 4000
Study Start date:
October 29, 2021
Estimated Completion Date:
September 30, 2026

Study Description

The scientific goal of the study is to establish the relationship between a variety of factors (lifetime environmental exposures, fitness and physical activity, biomarkers, nasal respiratory epithelial transcriptome) and ideal versus impaired peak lung health (reserve and markers of susceptibility in investigators' model) in young adulthood. In addition to the initial baseline assessment, remote contacts (e.g., via text message, email, mail, or phone) at regular intervals will allow for both the retention of the participants as well as the collection of additional short-term follow-up information, i.e., within 4.5 years of enrollment. If additional funding becomes available, investigators will extend the study for an additional period of time to study factors related to long-term changes in lung health over time, i.e., at 5 years and beyond. Recruitment of participants will be conducted by the participating study sites along with national and regional efforts from the American Lung Association. Recruitment efforts will be supported by the study web site www.lung.org/lung-study

Connect with a study center

  • University Of Alabama

    Birmingham, Alabama 35294
    United States

    Active - Recruiting

  • University of Arizona-Tuscon

    Tucson, Arizona 85724
    United States

    Active - Recruiting

  • University of California, Los Angeles

    Los Angeles, California 90095
    United States

    Active - Recruiting

  • University of California, San Francisco

    San Francisco, California 94143
    United States

    Active - Recruiting

  • University of Colorado

    Aurora, Colorado 80045
    United States

    Active - Recruiting

  • National Jewish Health

    Denver, Colorado 80206
    United States

    Active - Recruiting

  • Nemours Children's Jacksonville

    Jacksonville, Florida 32207
    United States

    Active - Recruiting

  • University of Florida, Jacksonville

    Jacksonville, Florida 32209
    United States

    Active - Recruiting

  • Northwestern University

    Chicago, Illinois 60611
    United States

    Active - Recruiting

  • Rush Universtiy

    Chicago, Illinois 60612
    United States

    Active - Recruiting

  • University of Chicago

    Chicago, Illinois 60637
    United States

    Site Not Available

  • University of Illinois at Chicago

    Chicago, Illinois 60608
    United States

    Active - Recruiting

  • St. Vincent's Health System

    Indianapolis, Indiana 46260
    United States

    Site Not Available

  • University of Iowa

    Iowa City, Iowa 52242
    United States

    Active - Recruiting

  • University of Kansas

    Kansas City, Kansas 66103
    United States

    Active - Recruiting

  • Johns Hopkins University

    Baltimore, Maryland 21218
    United States

    Active - Recruiting

  • Brigham and Women's

    Boston, Massachusetts 02115
    United States

    Site Not Available

  • University of Michigan

    Ann Arbor, Michigan 48109
    United States

    Active - Recruiting

  • Presbyterian Brooklyn Methodist Hospital

    Brooklyn, New York 11215
    United States

    Site Not Available

  • New York Medical College

    Hawthorne, New York 10532
    United States

    Site Not Available

  • Columbia University

    New York, New York 10032
    United States

    Site Not Available

  • Cornell University

    New York, New York 10032
    United States

    Active - Recruiting

  • Mt. Sinai, NYC

    New York, New York 10029
    United States

    Active - Recruiting

  • New York University

    New York, New York 10016
    United States

    Site Not Available

  • University of Rochester

    Rochester, New York 14642
    United States

    Active - Recruiting

  • University of North Carolina Hospital

    Chapel Hill, North Carolina 27517
    United States

    Active - Recruiting

  • Duke University

    Durham, North Carolina 27710
    United States

    Active - Recruiting

  • Wake Forest School of Medicine

    Winston-Salem, North Carolina 27104
    United States

    Active - Recruiting

  • Ohio State University

    Columbus, Ohio 43210
    United States

    Active - Recruiting

  • Temple University

    Philadelphia, Pennsylvania 19140
    United States

    Active - Recruiting

  • University of Pittsburg-Emphysema/COPD Research Center

    Pittsburgh, Pennsylvania 15213
    United States

    Active - Recruiting

  • Medical University of South Carolina

    Charleston, South Carolina 29425
    United States

    Active - Recruiting

  • Vanderbilt University Medical Center

    Nashville, Tennessee 37235
    United States

    Active - Recruiting

  • Baylor College of Medicine

    Houston, Texas 77030
    United States

    Active - Recruiting

  • University of Vermont

    Colchester, Vermont 05446
    United States

    Active - Recruiting

  • University of Washington

    Seattle, Washington 98108
    United States

    Site Not Available

  • University of Wisconsin Madison

    Madison, Wisconsin 53792
    United States

    Site Not Available

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