Topical Tranexamic Acid Use on Granulating Wounds Following Mohs Micrographic Surgery

Last updated: October 9, 2024
Sponsor: University of Missouri-Columbia
Overall Status: Completed

Phase

1

Condition

Hemorrhage

Treatment

Tranexamic acid

normal saline

Clinical Study ID

NCT04541303
2025444
  • Ages > 18
  • All Genders

Study Summary

Bleeding after Mohs micrographic surgery for skin cancer is a low risk complication that can occur. This study aims to determine the effect of a drug, often used to reduce bleeding, called tranexamic acid when applied topically to the skin wound after surgery.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • All adult (18 years or older) patients presenting for Mohs micrographic surgery (MMS) for the treatment of melanoma or nonmelanoma skin cancer (NMSC) with a woundthat will be healing by granulation

Exclusion

Exclusion Criteria:

  • Patients must not be pregnant or breastfeeding.

  • Patients must not have a known allergic reaction or sensitivity to TXA

  • Patient must not have an international normalized ratio (INR) out of therapeuticrange if on warfarin.

Study Design

Total Participants: 124
Treatment Group(s): 2
Primary Treatment: Tranexamic acid
Phase: 1
Study Start date:
October 08, 2020
Estimated Completion Date:
December 30, 2021

Study Description

To perform a prospective randomized controlled trial to determine the hemostatic effect of TXA soaked gauze (intervention) versus normal saline soaked gauze (control) when applied to granulating defects in the setting of Mohs micrographic surgery.

Patients meeting inclusion criteria will be randomized into two arms once enrolled in the study on the day of their Mohs micrographic surgery (MMS).

One arm will serve as the control group and will receive normal saline soaked telfa pads to the wound bed upon completion of MMS.

A second arm will receive TXA 25mg/ml at a volume of 1ml/cm2 soaked telfa pads to wound bed upon completion of MMS.

In both arms, the telfa pads will have a standard pressure dressing placed overtop.

Connect with a study center

  • University of Missouri-Columbia

    Columbia, Missouri 65212
    United States

    Site Not Available

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