Controlled Ovarian Hyperstimulation (COH) With Sequential HPFSH & HMG Versus Rec-F.S.H Alone in ICSI Cycle

Last updated: August 31, 2020
Sponsor: Alaa Fouli Gaber Ebrahim
Overall Status: Active - Recruiting

Phase

N/A

Condition

N/A

Treatment

N/A

Clinical Study ID

NCT04539613
COH in ICSI
  • Ages 20-35
  • Female

Study Summary

despite the large number of papers published on COH protocols comparing the efficiency of different exogenous gonadotropins, no confirmed protocol exists, and it is not quite clear which is superior to the others.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 1-Aged 20-35 yr, male factor, 2-Tubal or unexplained infertility, 3-regularmenstruation cycle between 21 and 35 days, 4-Normal function of uterus according tohysterosalpingography, hysteroscopy or transvaginal ultrasonography, 5-Normal ovariesaccording to transvaginal ultrasonography during past 6 months prior to study andcompatible with normal adnexa and 6-Normal ovarian anatomy, and serum FSH level lessthan 8 IU/l All women showed no recognizable endometriosis according to symptoms andclinical examination in transvaginal ultrasonography or diagnostic laparoscopy. 7-7-All women have a history of unexplained infertility 8-Normal ovulatory functionand normal semen analysis according to the World Health Organization criteria .

Exclusion

Exclusion Criteria:

  • Patients with other ovulation disorders such as hypo and hypergonadotropic,hypogonadism, hyperprolactinemia.

2-Thyroid disorders. 3-Ovarian or adrenal neoplasms. 4-Cushing syndrome. 5-previoushistory of systemic diseases such as endocrine and metabolic disorders.

6- Previous history of inappropriate ovarian response to stimulation withgonadotropins (poor responders).

7-Prior history of more than 3 unsucce

Study Design

Total Participants: 100
Study Start date:
September 01, 2020
Estimated Completion Date:
February 01, 2021

Study Description

, the objective of the current study was to compare the efficacy of 2 different ovarian stimulation protocols, comprising hpFSH, HMG versus R-FSH on oocyte and embryo quality and IVF treatment outcome in patients undergoing IVF or intracytoplasmic sperm injection (ICSI)(4).

Connect with a study center

  • El neel

    Minya,
    Egypt

    Active - Recruiting

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