Heart Rate Variability and Electroencephalography Analysis in Laparoscopic Surgery With or Without Transversus Abdominis Plane Block

Last updated: January 24, 2023
Sponsor: Mackay Memorial Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Anesthesia (Local)

Autonomic Nervous System

Treatment

N/A

Clinical Study ID

NCT04539080
20MMHIS210e
  • Ages > 20
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Heart rate variability(HRV) and electroencephalography(EEG) has been used widely in anesthetic practice nowadays. One of the most dominant applications is the nociception-analgesia balance. Some evidence support that heart rate variability correlates with perioperative stimulation and postoperative pain score. There are some new evidence support EEG correlated with anesthesia depth and analgesic balance. However, the heterogeneity between the studies and interference factors has limited their usage in clinical practice. On the other hand, peripheral nerve block is broadly used as a routine technique with general anesthesia, but few studies discuss the effect on heart rate variability. Our study focuses on the different HRV and EEG patterns of incision and insufflation during laparoscopic surgery with general anesthesia. Furthermore, we measure the effect of transversus abdominis plane nerve block to heart rate variability during surgery. By this comparison, we can discuss the influences of somatic stimulation, visceral stimulation, and pneumoperitoneum to heart rate variability, and then improve the accuracy of HRV-based nociception-analgesia monitors.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • ≥20 years of age male or female
  • American Society of Anesthesiologists (ASA) physical status classification I or II
  • capacity to give informed consent

Exclusion

Exclusion Criteria:

  • major cardiovascular and cerebral vascular disease, arrhythmia, respiratory disease,diabetes mellitus with evidence of neuropathy; ASA physical status classification IIIor greater; a documented or self-reported history of chronic pain; acute or chronicopioid analgesic use; dysautonomia; and intraoperative muscarinic anticholinergicadministration during the time of monitoring.

Study Design

Total Participants: 50
Study Start date:
August 30, 2020
Estimated Completion Date:
August 30, 2023

Connect with a study center

  • Taitung MacKay memorial hospital

    Taitung, Taitung, Taiwan
    Taiwan

    Active - Recruiting

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