Adaptive SCS for Treatment of Gait Disturbance in PD

Inclusion Criteria:

• 1,Parkinsonism(including idiopathic Parkinson's disease,Vascular Parkinson's disease,Atypical parkinsonism).

• 2, Aged 45-75 years old, Hoehn & Yahr stage (medication off condition) at 2~4;

• 3, Patients willingly seek surgical treatment for PD gait disturbance；

• 4, Walking disorder with freezing episodes, insufficiently alleviated by oraldopaminergic therapy and/or physiotherapy;

• 5, SCS eligibility has been confirmed by neurologist and neurosurgeon;

• 6, Ability to perform a gait/walking task (under close supervision);

• 7, Informed consent and have good compliance.

Exclusion Criteria:

• 1, Lesion in spinal cord or other surgical contraindications;

• 2, Other neuropsychiatric disorders or relevant medical history; haven't achieved theoptimal therapeutic effects of DBS surgery or drug therapy;

• 3, Medical history of stroke, amyotrophic lateral sclerosis or myasthenia gravis;taking prohibited medications (such as lithium, valproate, steroids, adrenergicagonists, etc.);

• 4, Cardiac, renal or other important organs hypofunction or dysfunction, or unstablevital signs;

• 5, Women reporting that they are pregnant;

• 6, Any situation (medical, psychological, social, geographical, etc.) that mayendanger patient's life or result in patients withdrawing from the study at present orin the future.