Dopamine Versus Norepinephrine Under General Anesthesia

Last updated: October 21, 2021
Sponsor: Children's Hospital of Fudan University
Overall Status: Completed

Phase

3

Condition

Congenital Heart Disease

Low Blood Pressure (Hypotension)

Pentalogy Of Cantrell

Treatment

N/A

Clinical Study ID

NCT04536194
mzk-0003-2020
  • Ages 1-12
  • All Genders

Study Summary

Participants under general anesthesia will be randomly treated with an adjusted dose dopamine or norepinephrine to elevate 10% of mean arterial pressure. Systemic hemodynamic data is recorded by PRAM and the change of cardiac index is compared between groups.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • undertake cardiac surgery for congenital heart disease

Exclusion

Exclusion Criteria:

  • Aortic valve or aortic disease
  • severe arrhythmia
  • use of cardiovascular active drugs before anesthesia
  • need to use a combination of different cardiovascular support drugs after anesthesia

Study Design

Total Participants: 60
Study Start date:
October 10, 2020
Estimated Completion Date:
September 30, 2021

Study Description

After intubation under general anesthesia, radial arterial is cannulated and pressure transducer is connected to MostCare(core technique PRAM). CI, SVRI, SVI, SVV, dp/dt and HR are recorded before and after a infusion of dopamine or norepinephrine to elevate 10% of mean arterial pressure. Changes of these hemodynamic data are compared.

Connect with a study center

  • Children's Hospital of Fudan University

    Shanghai, Shanghai 200000
    China

    Site Not Available

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