Open-Label Study of 18F-mFBG for Imaging Myocardial Sympathetic Innervation

Inclusion Criteria:

• ≥ 18 years of age at study entry

• able and willing to comply with study procedures

• signed and dated informed consent is obtained

• male or a female who is either surgically sterile (has had a documented bilateraloophorectomy and/or hysterectomy), postmenopausal (cessation of menses for more than 1 year), non-lactating, or of childbearing potential for whom the result of a serumpregnancy test performed at screening is negative.

For control subjects:

• Subject is either:

• <40 years old and has a likelihood assessment for CAD <10%, or

• 40-50 years old, has a likelihood assessment for CAD <10%, and a normal stressMPI study or stress echocardiography performed within 6 months before studyentry, or

• Without significant coronary atherosclerotic disease (no arterial stenosis with >30% narrowing) as demonstrated by a coronary angiography performed with 6months before study entry.

For heart failure subjects:

• Diagnosed with HF at least 1 year before enrollment.

• HF classification NYHA Class II at enrollment.

• Rest left ventricular ejection fraction (LVEF) ≤35% measured by an appropriatemethod (e.g., radionuclide or contrast ventriculography, ECG-gated SPECT MPI, orechocardiography) within 180 days prior to the study imaging procedure, with nochange in clinical condition since the LVEF measurement.

• Primary prevention ICD, implanted at least 6 months before enrollment.

• Clinically stable for at least 30 days before enrollment (e.g., not experiencingcontinuing chest pain, hemodynamic instability, or clinically significant arrhythmia (including ICD discharge)) and remains stable to the time of the study imagingprocedure.

Exclusion Criteria:

• Previously entered into this study or has participated in any other investigationalmedicinal product or medical device study within 30 days of enrollment.

• History or suspicion of significant allergic reaction or anaphylaxis to anycomponents of the 18F-mFBG imaging agent.

• Ventricular pacemaker that routinely functions (>5% paced beats)

• Cardiac revascularization (e.g., percutaneous transluminal coronary angioplasty,PCI, or CABG), or an acute myocardial infarction within the past 30 days.

• Presents with any other clinically active, serious, life-threatening disease with alife expectancy of less than 1 year or where participation in the study mightcompromise the management of the subject or other reason that in the judgment of theinvestigator(s) makes the subject unsuitable for participation in the study.

• Serious non-cardiac medical condition associated with significant elevation ofplasma catecholamines including pheochromocytoma.

• Claustrophobic or has a movement disorder that prevents him/her from lying still ina supine position for up to an hour at a time.

• Renal insufficiency (serum creatinine >3.0 mg/dL).

• Use of medications that are known to interfere with uptake of NET-dependent agentsand these medications cannot be safely withheld 24 hours before study procedures.

• Participated in a research study using ionizing radiation in the previous 12 months.

• For control subjects: a history of Type I or Type II Diabetes Mellitus,signs/symptoms of neurological disease (e.g., Parkinson's Disease, Multiple SystemAtrophy, Parkinsonian syndromes), or other diseases known to affect the sympatheticnervous system.