The UPPROACH (Upfront Intensity Modulated Proton Beam Therapy) Approach

Inclusion Criteria:

1. Surgery must have included a hysterectomy. Bilateral salpingo-oophorectomy, pelviclymph node sampling, para-aortic lymph node sampling, and omentectomy are optional

2. Patients will be staged according to FIGO 2009 staging system. Eligibility isdefined based on clinical-pathologic features.

3. Patients with endometrioid endometrial cancer with the following:

• Stage IA grade 3 with extensive LVSI

• Stage IB grade 3

• Stage II

• Stage III (A, B, and C)

• Stage IVA who are recommended adjuvant whole pelvic RT (+/- lower para-aorticup to renal hilum) and systemic chemotherapy.

4. Patients with clear cell, serous papillary carcinoma, or carcinosarcoma with stagesIA-III who are recommended adjuvant whole pelvic RT (+/- lower para-aortic up torenal hilum) and systemic chemotherapy.

5. Patients with a GOG Performance Status of 0, 1, or 2

6. Patients with adequate organ function, reflected by the following parameters:

• WBC ≥ 3000/mcl

• Absolute neutrophil count (ANC) ≥ 1000/mcl

• Platelet count ≥ 100,000/mcl

• SGOT, SGPT, and alkaline phosphatase ≤ 2.5 X upper limit of normal (ULN)

• Bilirubin ≤ 1.5 X ULN

• Creatinine ≤ institutional ULN (if serum creatinine > ULN, estimated GFR ≥ 45ml/min)

7. Patients who have signed an approved informed consent and authorization permittingrelease of personal health information

8. Patients must be 18 years of age or older

Exclusion Criteria:

1. Patients with leiomyosarcoma

2. Patients with clinically significant pelvic or para-aortic nodal disease, onpost-surgery CT scan, that was not dissected and would require higher boost dose

3. Patients with recurrent endometrial cancer with gross nodal or vaginal diseaserequiring high dose radiotherapy, or history of prior chemotherapy

4. Patients with a history of prior pelvic/abdominal RT or with history of prior cancertreatment that contraindicates this protocol therapy including history of priorchemotherapy for any other malignancy.

5. Patients with a history of serious co-morbid illness or uncontrolled illnesses thatwould preclude protocol therapy

6. Patients with an estimated survival of less than three months

7. Patients with FIGO 2009 Stage IVB endometrial cancer

8. Patients with a history of myocardial infarction, unstable angina, or uncontrolledarrhythmia within 3 months from enrollment