Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke With Mild Symptoms

Last updated: August 25, 2020
Sponsor: Shanghai East Hospital
Overall Status: Completed

Phase

N/A

Condition

Cerebral Ischemia

Stroke

Blood Clots

Treatment

N/A

Clinical Study ID

NCT04526756
2016-DFNE-002
  • Ages > 18
  • All Genders

Study Summary

Mechanical thrombectomy(MT) has been recommended in patients with acute large vessel occlusion stroke(LVO) , especially for those with National Institutes of Health Stroke Scale (NIHSS) score ≥6. However, it is still unclear if patients with minor strokes and LVO also benefit from MT.The aim of this study was to evaluate the safety and efficacy of MT for acute LVO and mild symptoms.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. acute ischemic stroke within 24 hours of symptom onset presenting cortical symptoms (such as aphasia, somnolence,slow-minded,etc.) or vertigo with bilateral pathologicalsigns;

  2. age≥18 years old;

  3. the NIHSS score before evaluation of thrombectomy<6;

  4. large artery occlusion including Middle cerebral artery M1, proximal M2 segment,intracranial internal carotid artery and infarct core volume≤50ml and mismatchratio>1.8 or basilar artery and posterior cerebral artery P1 occlusion

Exclusion

Exclusion Criteria:

  1. Patients without prior functional independence (mRS score of >2)

  2. Patients in intervention group with occlusive artery spontaneous recanalization indigital subtraction angiography

  3. patients in control group with neurological worsening and received rescue thrombectomy

Study Design

Total Participants: 105
Study Start date:
July 01, 2016
Estimated Completion Date:
June 20, 2020

Study Description

This is a prospective cohort study of patients with with mild ischemic stroke (NIHSS Score <6) and LVO. Patients were divided into 2 groups: MT or medical management.Baseline data and clinical outcomes were compared. A independent clinical outcome was defined as a modified Rankin Scale score of 0 to 2 at 90 days. A excellent clinical outcome was defined as a modified Rankin Scale score of 0 to 1 at 90 days. Symptomatic intracranial hemorrhage(sICH) was the safety outcome.

Connect with a study center

  • Gang Li

    Shanghai, Shanghai 200123
    China

    Site Not Available

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