MSC-based Therapy in COVID-19-associated Acute Respiratory Distress Syndrome

Inclusion Criteria:

• Clinical diagnosis of COVID-19 confirmed by RT-PCR;

• Thorax CT image suggestive of viral pneumonia;

• Respiratory failure (SaO2 <93% with O2 at 5L / min)

• Tracheal intubation (first 48 h);

Exclusion Criteria:

• Pregnancy or breastfeeding;

• Patients with a history of cancer, chemotherapy in the past 2 years;

• Life expectancy less than 6 months or in exclusive palliative care;

• Severe liver failure, with Child-Pugh score> 12;

• High probability of death in the following 48 h;

• Previous renal failure: patients who were already on dialysis or patients with RFG <30ml / min / 1.73 m2;

• Clinical or radiological suspicion of tuberculosis and bacterial pneumonia.