Phase
Condition
Renal Failure
Kidney Failure
Kidney Disease
Treatment
Conventional Hemodialysis
Online Post-dilution Hemodiafiltration
Online Pre-dilution Hemodiafiltration
Clinical Study ID
Ages > 18 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Hospitalised in the ICU
Acute kidney injury stage 3 (KDIGO-AKI Criteria)
Requiring RRT for AKI, as judged by the attending clinician (initiation) orconversion from CRRT to intermittent dialysis
Adult of 18 years or more
Exclusion
Exclusion Criteria:
Female subjects who are pregnant or breast-feeding or considering becoming pregnantduring the study.
Subjects who are participating in another study involving dialysis interventions
Subjects or relatives/next-of-kin unable to provide written informed consent
Creatinine clearance (CrCl) < 30 mL/min measured by 24-hour urine collection or eGFRor on chronic dialysis at baseline
Subjects on active immunosuppressive therapy (>10mg of prednisone, biologictherapies, calcineurin inhibitors, mTOR inhibitors or antimetabolites)
Subjects with active contraindication to anticoagulation during dialysis session
Subjects whose RRT is not part of their life goal
Study Design
Study Description
Connect with a study center
Centre de recherche du CHUM
Montreal, Quebec H2X 0C1
CanadaSite Not Available
Clinical Research Centre University College Dublin
Dublin,
IrelandSite Not Available
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