Misfolded Proteins in the Skin of People With Parkinson's Disease and Other Parkinsonism

Inclusion Criteria:

• Age 21 years old and age <90 years of age at the time of the baseline visit 1

• Age of diagnosis at least 40 years old for PD, DLB, and PSP and at least 30 yearsold for MSA

• A confirmed diagnosis of PD, PSP, CBD, MSA, DLB, or healthy control

• Montreal Cognitive Assessment (MoCA) > 10 at the outset of the study

Exclusion Criteria:

• Age 90 or above

• Allergy to local anesthetic

• History of deep brain stimulation (DBS) or other brain surgery prior to Visit 1

• For PD or DLB diagnoses, any other neurodegenerative or central nervous systemprocess that would interfere with examination

• For PD or DLB, history of negative DATscan

• Use of investigational drugs or devices within 60 days prior to baseline visit (except for dietary supplements)

• In control subjects, family history of a neurodegenerative disease in a first degreeor second degree blood relative

• History of schizophrenia

• History of antipsychotic medication use or exposure in controls or history ofantipsychotic medication leading to parkinsonism (drug induced parkinsonism) in theparkinsonism group

• Blood clotting disorder

• On multiple (more than one) antiplatelet and/or anticoagulant blood thinnermedications in combination (except for aspirin if it can be safely held for 1 week)

• Any other medical, psychiatric, or cognitive illness that in the investigator'sopinion would interfere with cooperation or ability to undergo the study procedures.