Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy

Last updated: December 18, 2024
Sponsor: University of Aberdeen
Overall Status: Active - Recruiting

Phase

N/A

Condition

Heart Disease

Congestive Heart Failure

Circulation Disorders

Treatment

Blood collection for genetic analysis

Clinical Study ID

NCT04513054
2-025-18
  • All Genders

Study Summary

Acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious health consequences. In the current study the investigators wish to establish whether there is a genetic predisposition making certain people more susceptible to this condition. This could also have implications for their families.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • All patients who have been diagnosed with Takotsubo cardiomyopathy in Scotlandbetween 2010 to date.

  • Familial cases elsewhere in the world who would be willing to participate.

Exclusion

Exclusion Criteria:

  • Unwillingness to participate

Study Design

Total Participants: 700
Treatment Group(s): 1
Primary Treatment: Blood collection for genetic analysis
Phase:
Study Start date:
March 12, 2019
Estimated Completion Date:
December 31, 2028

Study Description

Acute stress-induced (takotsubo) cardiomyopathy presents like a myocardial infarct, is triggered by intense emotional or physical stress, and can have catastrophic and potentially fatal consequences. Despite data linking takotsubo cardiomyopathy with conditions that have a recognized genetic predisposition (such as mental health and neurological problems), a systematic and comprehensive characterisation of the genetic-epidemiologic factors in takotsubo is lacking. The researchers propose to further investigate this disorder by collecting blood from probands and characterising the genotype of patients with takotsubo cardiomyopathy in a large scale, nationwide genome wide association study. The investigators will also archive DNA for identification of future candidate genetic variants. Ultimately, understanding the underlying predisposition of this poorly understood neuro-psycho-cardiac disorder is essential if we are to move this field forward.

Connect with a study center

  • Cardiovascular Research Facility

    Aberdeen, Aberdeenshire AB25 2ZD
    United Kingdom

    Active - Recruiting

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