Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patients:

Last updated: March 3, 2025
Sponsor: The Cleveland Clinic
Overall Status: Completed

Phase

3

Condition

Cardiac Disease

Treatment

Norepinephrine

Vasopressin

Clinical Study ID

NCT04501861
20-301
  • Ages > 19
  • All Genders

Study Summary

The relative increase in the mPAP with the same unit increase in MAP adjusted for baseline, and RV function assessed by GLS, between VP and NE in patients with normal and increased pulmonary artery pressure, who require vasopressor support during cardiac surgery.

Eligibility Criteria

Inclusion

Inclusion criteria:

Adults> 18 years of age

  • Elective cardiac surgery with the use of CPB

  • Patients with pulmonary artery catheter insertion

  • Systemic hypotension (MAP < 70 mmHg) requiring continuous infusion of vasopressor

Exclusion

Exclusion Criteria:

  • Transplant surgery

  • Ventricular assist device implantation other than intra-aortic ballooncounter-pulsation

  • Pulmonary endarterectomy

  • Thoracoabdominal aneurysm repair

  • Inhalational pulmonary vasodilators (e.g. Epoprostenol) administration beforeinsertion of pulmonary artery catheter

  • Vasopressin is started as the first choice of pressor per clinical staff discretion

Study Design

Total Participants: 153
Treatment Group(s): 2
Primary Treatment: Norepinephrine
Phase: 3
Study Start date:
November 05, 2020
Estimated Completion Date:
December 31, 2024

Study Description

The specific aims of our study are to compare 1) the relative increase in the mPAP with the same unit increase in MAP adjusted for baseline and 2) RV function assessed by GLS, between VP and NE in patients with normal and increased pulmonary artery pressure, who require vasopressor support during cardiac surgery. We hypothesize that the use of vasopressin compared with norepinephrine induces a lower mPAP-to-MAP ratio, in cardiac surgical patients with and without pulmonary hypertension who require intraoperative vasopressor support. Second, we will test the hypothesis that vasopressin is associated with improved right ventricular global longitudinal strain compared to norepinephrine in patients requiring vasopressor support during cardiac surgery.

Connect with a study center

  • Cleveland Clinic

    Cleveland, Ohio 44195
    United States

    Site Not Available

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