Hemodynamic Effects of ARNI on Noninvasive Pressure-volume Analysis in Patients With Chronic Heart Failure

Last updated: April 7, 2026
Sponsor: University of Leipzig
Overall Status: Completed

Phase

N/A

Condition

Heart Failure

Chest Pain

Hyponatremia

Treatment

Sacubitril-Valsartan

Clinical Study ID

NCT04498780
DL-L-20005_V1.4
  • Ages > 18
  • All Genders

Study Summary

Sacubitril-Valsartan reduced heart failure hospitalizations and cardiovascular mortality compared to enelapril in chronic heart failure. Furthermore, quality of life is improved. The decrease of NT-proBNP levels during Sacubitril-Valsartan treatment is associated with reverse left ventricular remodeling and improved left ventricular systolic function. However, the underlying mechanisms that contribute to these symptomatic and prognostic benefits are largely unknown. The aim of this study is to evaluate left ventricular hemodynamics in patients treated with Sacubitril-Valsartan using non-invasive pressure-volume analysis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Symptomatic heart failure (NYHA functional class II to IV)

  • Reduced LV ejection fraction (≤ 40%)

  • Clinical indication for therapy with Sacubitril-Valsartan

Exclusion

Exclusion Criteria:

  • catecholamine therapy at inclusion

  • existing therapy with Sacubitril-Valsartan

  • planned cardiac resynchronization therapy (CRT) within 6 months; inclusion at least 3 months after CRT

  • planned mitral or aortic valve procedure within 6 months; inclusion at least 3months after valve procedure

  • participation in another randomized heart failure trial

  • severe aortic or mitral valve lesion

Study Design

Total Participants: 117
Treatment Group(s): 1
Primary Treatment: Sacubitril-Valsartan
Phase:
Study Start date:
July 21, 2020
Estimated Completion Date:
April 08, 2026

Connect with a study center

  • University of Leipzig

    Leipzig, Saxony 04103
    Germany

    Site Not Available

  • Kardiopraxis Schirmer

    Kaiserslautern,
    Germany

    Site Not Available

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