Making Informed Choices on Incorporating Chemoprevention Into Care (MiCHOICE)

Last updated: May 7, 2025
Sponsor: SWOG Cancer Research Network
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Carcinoma

Ductal Carcinoma In Situ (Dcis)

Breast Cancer

Treatment

Questionnaire Administration

Decision Aid

Interview

Clinical Study ID

NCT04496739
S1904
R01CA226060
NCI-2019-08755
UG1CA189974
S1904
SWOG-S1904
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This trial studies the implementation of web-based decision support tools for patients with atypical hyperplasia or lobular carcinoma in situ and healthcare providers. Decision support tools are designed to improve informed choice about breast cancer chemoprevention. Recognizing barriers and facilitators that can influence the adoption of decision support tools at recruitment centers may help researchers learn how to best implement them into clinical practice.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients must have histologically-confirmed atypical hyperplasia (AH) or lobularcarcinoma in situ (LCIS) documented by breast pathology report at any time in thepast. Patients with borderline breast lesions and pleomorphic LCIS are also eligible

  • Patients must be women at least 35 and no more than 74 years of age at registration,since the Breast Cancer Surveillance Consortium (BCSC) risk calculator is valid onlyfor this age range

  • Both pre/perimenopausal and postmenopausal women are eligible

  • Patients must be able to read and write in English or Spanish since studyquestionnaires and educational materials are only available in English and Spanish

  • Baseline questionnaires must be completed prior to patient registration

  • The S1904 Patient Contact form must be completed prior to patient registration

  • Patients must be able to access the internet and receive email or text messages.This is required to access study materials and receive email/text message remindersfrom the S1904 Study Team at Columbia University Irving Medical Center (CUIMC). Thepatient decision aid, RealRisks, is accessible via smartphones, tablets, or personalcomputers. If patients do not own these devices, local study personnel will provideresources for patients to access RealRisks via computer kiosks or tablets in clinicwaiting rooms or public locations, such as community centers or public libraries

  • Patients and healthcare providers must be informed of the investigational nature ofthis study and must sign and give written informed consent in accordance withinstitutional and federal guidelines

  • As a part of the Oncology Patient Enrollment Network (OPEN) registration process thetreating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study hasbeen entered in the system

  • IMPLEMENTATION: Providers who enrolled in S1904 at Group 2 (intervention)recruitment center and consented to future contact are eligible to participate inthe interviews

  • IMPLEMENTATION EVALUATION: Patients who registered to S1904 at a Group 2 (Intervention) Recruitment Center and consented to be contacted for future researchare eligible to participate in the interviews

  • Recruitment Centers must be National Clinical Trials Network (NCTN), National CancerInstitute Community Oncology Research Program (NCORP) or Minority Underserved (MU)-NCORP institutions

  • Recruitment Centers must have an active EHR and patient portal used in theoutpatient clinics which is common and accessible across all sites belonging to theRecruitment Center

  • Recruitment Centers must be willing to allow the S1904 study team access to thesite's application program interface (API) for integration of the study materials (standard educational materials and decision support tools) into the EHR and patientportal. (NOTE: Both Group 1 (control) and Group 2 (intervention) recruitment centersmay access the standard educational materials via the patient portal or uniformresource locator (URL)/website)

  • Recruitment centers must see at least 50 AH and/or LCIS patients per year

  • Recruitment centers must identify a lead principal investigator (PI) to facilitaterecruitment and retention of patients and healthcare providers and to participate inquarterly stakeholder meetings/conference calls

  • Recruitment centers must be willing to register at about 16 patients and 5healthcare providers to the study

  • Recruitment Centers must be willing to submit monthly screening logs to CUIMC

  • Providers must regularly see patients with AH or LCIS at an approved recruitmentcenter

  • Providers must be willing to provide informed consent and complete an onlinebaseline questionnaire

  • Providers who will register patients must be registered members of a CooperativeGroup

  • Providers who register patients to S1904 must be willing to see those same patientsfor their 6-month study visits, as the provider intervention tools require that the "treating investigator" as designated in OPEN and the provider at the 6-month studyvisit be the same

Exclusion

Exclusion Criteria:

  • Patients must not have a history of invasive breast cancer or ductal carcinoma insitu

  • Patients must not have prior or current use of selective estrogen receptormodulators (SERMs) or aromatase inhibitors (AIs)

  • NOTE: The following are approved SERMS and AIs, however, the study is notlimited to these.

  • SERMs: tamoxifen, raloxifene

  • AIs: anastrozole, exemestane, letrozole

  • Patients must not be currently taking hormone replacement therapy

  • Patients must not have a history of bilateral mastectomies or breast implants sincethe risk calculator is not applicable to these women

  • Patients must not be pregnant or lactating

  • Premenopausal patients must not have a history of thromboembolism, since it is acontraindication to tamoxifen. Tamoxifen is the only Food and Drug Administration (FDA)-approved drug for breast cancer chemoprevention among high-risk premenopausalwomen, whereas postmenopausal women are eligible for both SERMs and AIs

Study Design

Total Participants: 412
Treatment Group(s): 4
Primary Treatment: Questionnaire Administration
Phase:
Study Start date:
October 23, 2020
Estimated Completion Date:
June 01, 2028

Study Description

PRIMARY OBJECTIVE:

I. To compare the frequency of chemoprevention informed choice at 6 months after registration among women with atypical hyperplasia (AH) or lobular carcinoma in situ (LCIS) between the intervention (RealRisks decision aid/breast cancer risk navigation [BNAV] + standard educational materials) and control (standard educational materials alone) arms.

SECONDARY OBJECTIVES:

I. To assess patient chemoprevention knowledge, chemoprevention intention/decision, perceived breast cancer risk and worry, accuracy of breast cancer risk perception, decision conflict and decision regret at baseline, 6 months, and 12 months in the intervention and control arms.

II. To compare patient chemoprevention usage, adherence, and reasons for discontinuation of a selective estrogen receptor modulator (SERM) or aromatase inhibitor (AI) annually for up to 5 years between the intervention and control arms.

III. To assess shared decision-making about chemoprevention among patients and healthcare providers after their 6-month clinic visit in the intervention and control arms.

IMPLEMENTATION OBJECTIVE:

I. To assess the implementation of the decision support tools, RealRisks and BNAV, into clinic workflow, and to better understand barriers and facilitators to chemoprevention usage by conducting telephone/video-conference interviews of healthcare providers and high-risk women with AH or LCIS assigned to the active intervention.

OUTLINE: Recruitment centers are randomized to 1 of 2 groups.

GROUP I (CONTROL): Patients receive standard educational materials about breast cancer risk and chemoprevention in RealRisks via the patient portal or website.

GROUP II (INTERVENTION): Patients receive standard educational materials about breast cancer risk and chemoprevention in RealRisks via the patient portal or website. Patients receive patient-centered decision support within the patient portal via an action plan summarizing their breast cancer risk profile, their risks and benefits of SERMs and AIs, and personal preferences for chemoprevention. Health care providers receive decision support and action plans based on their patients' interactions with RealRisks via the BNAV provider-centered support tool within the electronic health record (EHR). A sample of patients participate in an audio-recorded interview via telephone or video conference over 45-60 minutes at 12 months after registration. A sample of health care providers participate in 3 audio-recorded interviews via telephone or video conference over 45-60 minutes each at baseline, within 12-36 months after study activation, and within 12 months after study closure to accrual.

After completion of study, patients are followed up at 6, 12, 24, 36, 48, and 60 months.

Connect with a study center

  • FHP Health Center-Guam

    Tamuning, 96913
    Guam

    Site Not Available

  • Kaiser Permanente-Deer Valley Medical Center

    Antioch, California 94531
    United States

    Site Not Available

  • UC Irvine Health Cancer Center-Newport

    Costa Mesa, California 92627
    United States

    Site Not Available

  • City of Hope Comprehensive Cancer Center

    Duarte, California 91010
    United States

    Site Not Available

  • Kaiser Permanente-Oakland

    Oakland, California 94611
    United States

    Site Not Available

  • UC Irvine Health/Chao Family Comprehensive Cancer Center

    Orange, California 92868
    United States

    Site Not Available

  • Kaiser Permanente Downtown Commons

    Sacramento, California 95814
    United States

    Site Not Available

  • Kaiser Permanente-South Sacramento

    Sacramento, California 95823
    United States

    Site Not Available

  • Kaiser San Rafael-Gallinas

    San Rafael, California 94903
    United States

    Site Not Available

  • Kaiser Permanente Medical Center - Santa Clara

    Santa Clara, California 95051
    United States

    Site Not Available

  • City of Hope South Pasadena

    South Pasadena, California 91030
    United States

    Site Not Available

  • Kaiser Permanente-South San Francisco

    South San Francisco, California 94080
    United States

    Site Not Available

  • Kaiser Permanente-Vallejo

    Vallejo, California 94589
    United States

    Site Not Available

  • Kaiser Permanente-Walnut Creek

    Walnut Creek, California 94596
    United States

    Site Not Available

  • Mount Sinai Comprehensive Cancer Center at Aventura

    Aventura, Florida 33180
    United States

    Site Not Available

  • Miami Cancer Institute

    Miami, Florida 33176
    United States

    Site Not Available

  • Mount Sinai Medical Center

    Miami Beach, Florida 33140
    United States

    Site Not Available

  • Miami Cancer Institute at Plantation

    Plantation, Florida 33324
    United States

    Site Not Available

  • Emory Saint Joseph's Hospital

    Atlanta, Georgia 30342
    United States

    Site Not Available

  • Emory University Hospital Midtown

    Atlanta, Georgia 30308
    United States

    Site Not Available

  • Emory University Hospital/Winship Cancer Institute

    Atlanta, Georgia 30322
    United States

    Site Not Available

  • Grady Health System

    Atlanta, Georgia 30303
    United States

    Site Not Available

  • Hawaii Cancer Care - Westridge

    'Aiea, Hawaii 96701
    United States

    Site Not Available

  • Pali Momi Medical Center

    'Aiea, Hawaii 96701
    United States

    Site Not Available

  • Queen's Cancer Center - Pearlridge

    'Aiea, Hawaii 96701
    United States

    Site Not Available

  • The Cancer Center of Hawaii-Pali Momi

    'Aiea, Hawaii 96701
    United States

    Site Not Available

  • The Queen's Medical Center - West Oahu

    'Ewa Beach, Hawaii 96706
    United States

    Site Not Available

  • Hawaii Cancer Care Inc - Waterfront Plaza

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Hawaii Cancer Care Inc-Liliha

    Honolulu, Hawaii 96817
    United States

    Site Not Available

  • Hawaii Diagnostic Radiology Services LLC

    Honolulu, Hawaii 96817
    United States

    Site Not Available

  • Kapiolani Medical Center for Women and Children

    Honolulu, Hawaii 96826
    United States

    Site Not Available

  • Kuakini Medical Center

    Honolulu, Hawaii 96817
    United States

    Site Not Available

  • Queen's Cancer Cenrer - POB I

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Queen's Cancer Center - Kuakini

    Honolulu, Hawaii 96817
    United States

    Site Not Available

  • Queen's Medical Center

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Straub Clinic and Hospital

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • The Cancer Center of Hawaii-Liliha

    Honolulu, Hawaii 96817
    United States

    Site Not Available

  • University of Hawaii Cancer Center

    Honolulu, Hawaii 96813
    United States

    Site Not Available

  • Straub Medical Center - Kahului Clinic

    Kahului, Hawaii 96732
    United States

    Site Not Available

  • Castle Medical Center

    Kailua, Hawaii 96734
    United States

    Site Not Available

  • Wilcox Memorial Hospital and Kauai Medical Clinic

    Lihue, Hawaii 96766
    United States

    Site Not Available

  • Loyola Center for Health at Burr Ridge

    Burr Ridge, Illinois 60527
    United States

    Site Not Available

  • Centralia Oncology Clinic

    Centralia, Illinois 62801
    United States

    Site Not Available

  • Advocate Illinois Masonic Medical Center

    Chicago, Illinois 60657
    United States

    Site Not Available

  • Carle at The Riverfront

    Danville, Illinois 61832
    United States

    Site Not Available

  • Carle on Vermilion

    Danville, Illinois 61832
    United States

    Active - Recruiting

  • Cancer Care Specialists of Illinois - Decatur

    Decatur, Illinois 62526
    United States

    Site Not Available

  • Carle Physician Group-Effingham

    Effingham, Illinois 62401
    United States

    Site Not Available

  • Crossroads Cancer Center

    Effingham, Illinois 62401
    United States

    Site Not Available

  • Carle Physician Group-Mattoon/Charleston

    Mattoon, Illinois 61938
    United States

    Site Not Available

  • Loyola University Medical Center

    Maywood, Illinois 60153
    United States

    Site Not Available

  • Cancer Care Center of O'Fallon

    O'Fallon, Illinois 62269
    United States

    Site Not Available

  • Advocate Lutheran General Hospital

    Park Ridge, Illinois 60068
    United States

    Site Not Available

  • Carle Cancer Center

    Urbana, Illinois 61801
    United States

    Site Not Available

  • The Carle Foundation Hospital

    Urbana, Illinois 61801
    United States

    Site Not Available

  • IU Health West Hospital

    Avon, Indiana 46123
    United States

    Site Not Available

  • IU Health North Hospital

    Carmel, Indiana 46032
    United States

    Site Not Available

  • Indiana University/Melvin and Bren Simon Cancer Center

    Indianapolis, Indiana 46202
    United States

    Site Not Available

  • Sidney and Lois Eskenazi Hospital

    Indianapolis, Indiana 46202
    United States

    Site Not Available

  • Beverly Hospital

    Beverly, Massachusetts 01915
    United States

    Site Not Available

  • Dana-Farber Cancer Institute

    Boston, Massachusetts 02215
    United States

    Site Not Available

  • Lahey Hospital and Medical Center

    Burlington, Massachusetts 01805
    United States

    Site Not Available

  • Addison Gilbert Hospital

    Gloucester, Massachusetts 01930
    United States

    Site Not Available

  • Winchester Hospital

    Winchester, Massachusetts 01890
    United States

    Site Not Available

  • Borgess Medical Center

    Kalamazoo, Michigan 49048
    United States

    Site Not Available

  • West Michigan Cancer Center

    Kalamazoo, Michigan 49007
    United States

    Site Not Available

  • Mayo Clinic in Rochester

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • Memorial Sloan Kettering Basking Ridge

    Basking Ridge, New Jersey 07920
    United States

    Site Not Available

  • Memorial Sloan Kettering Monmouth

    Middletown, New Jersey 07748
    United States

    Site Not Available

  • Memorial Sloan Kettering Bergen

    Montvale, New Jersey 07645
    United States

    Site Not Available

  • Memorial Sloan Kettering Commack

    Commack, New York 11725
    United States

    Site Not Available

  • Memorial Sloan Kettering Westchester

    Harrison, New York 10604
    United States

    Site Not Available

  • Memorial Sloan Kettering Cancer Center

    New York, New York 10065
    United States

    Site Not Available

  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

    New York, New York 10032
    United States

    Site Not Available

  • Memorial Sloan Kettering Nassau

    Uniondale, New York 11553
    United States

    Site Not Available

  • Sanford Roger Maris Cancer Center

    Fargo, North Dakota 58122
    United States

    Site Not Available

  • Cleveland Clinic Foundation

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • Ohio State University Comprehensive Cancer Center

    Columbus, Ohio 43210
    United States

    Site Not Available

  • Good Samaritan Hospital

    Corvallis, Oregon 97330
    United States

    Site Not Available

  • Providence Portland Medical Center

    Portland, Oregon 97213
    United States

    Site Not Available

  • Providence Saint Vincent Medical Center

    Portland, Oregon 97225
    United States

    Site Not Available

  • Holy Redeemer Hospital and Medical Center

    Meadowbrook, Pennsylvania 19046
    United States

    Site Not Available

  • Sanford Cancer Center Oncology Clinic

    Sioux Falls, South Dakota 57104
    United States

    Site Not Available

  • Baptist Memorial Hospital and Cancer Center-Collierville

    Collierville, Tennessee 38017
    United States

    Site Not Available

  • Baptist Memorial Hospital and Cancer Center-Memphis

    Memphis, Tennessee 38120
    United States

    Site Not Available

  • Baptist Memorial Hospital for Women

    Memphis, Tennessee 38120
    United States

    Site Not Available

  • Huntsman Cancer Institute/University of Utah

    Salt Lake City, Utah 84112
    United States

    Site Not Available

  • Peninsula Cancer Institute-Newport News

    Newport News, Virginia 23601
    United States

    Site Not Available

  • VCU Massey Cancer Center at Stony Point

    Richmond, Virginia 23235
    United States

    Site Not Available

  • Virginia Cancer Institute

    Richmond, Virginia 23229
    United States

    Site Not Available

  • Virginia Commonwealth University/Massey Cancer Center

    Richmond, Virginia 23298
    United States

    Site Not Available

  • VCU Community Memorial Health Center

    South Hill, Virginia 23970
    United States

    Site Not Available

  • Shenandoah Oncology PC

    Winchester, Virginia 22601
    United States

    Site Not Available

  • Mayo Clinic Health System-Eau Claire Clinic

    Eau Claire, Wisconsin 54701
    United States

    Site Not Available

  • University of Wisconsin Carbone Cancer Center

    Madison, Wisconsin 53792
    United States

    Site Not Available

  • University of Wisconsin Hospital and Clinics

    Madison, Wisconsin 53792
    United States

    Active - Recruiting

  • Aurora Saint Luke's Medical Center

    Milwaukee, Wisconsin 53215
    United States

    Site Not Available

  • Vince Lombardi Cancer Clinic-Two Rivers

    Two Rivers, Wisconsin 54241
    United States

    Site Not Available

  • Aurora West Allis Medical Center

    West Allis, Wisconsin 53227
    United States

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.