Phase
Condition
Carcinoma
Ductal Carcinoma In Situ (Dcis)
Breast Cancer
Treatment
Questionnaire Administration
Decision Aid
Interview
Clinical Study ID
All Genders Accepts Healthy Volunteers
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
Patients must have histologically-confirmed atypical hyperplasia (AH) or lobularcarcinoma in situ (LCIS) documented by breast pathology report at any time in thepast. Patients with borderline breast lesions and pleomorphic LCIS are also eligible
Patients must be women at least 35 and no more than 74 years of age at registration,since the Breast Cancer Surveillance Consortium (BCSC) risk calculator is valid onlyfor this age range
Both pre/perimenopausal and postmenopausal women are eligible
Patients must be able to read and write in English or Spanish since studyquestionnaires and educational materials are only available in English and Spanish
Baseline questionnaires must be completed prior to patient registration
The S1904 Patient Contact form must be completed prior to patient registration
Patients must be able to access the internet and receive email or text messages.This is required to access study materials and receive email/text message remindersfrom the S1904 Study Team at Columbia University Irving Medical Center (CUIMC). Thepatient decision aid, RealRisks, is accessible via smartphones, tablets, or personalcomputers. If patients do not own these devices, local study personnel will provideresources for patients to access RealRisks via computer kiosks or tablets in clinicwaiting rooms or public locations, such as community centers or public libraries
Patients and healthcare providers must be informed of the investigational nature ofthis study and must sign and give written informed consent in accordance withinstitutional and federal guidelines
As a part of the Oncology Patient Enrollment Network (OPEN) registration process thetreating institution's identity is provided in order to ensure that the current (within 365 days) date of institutional review board approval for this study hasbeen entered in the system
IMPLEMENTATION: Providers who enrolled in S1904 at Group 2 (intervention)recruitment center and consented to future contact are eligible to participate inthe interviews
IMPLEMENTATION EVALUATION: Patients who registered to S1904 at a Group 2 (Intervention) Recruitment Center and consented to be contacted for future researchare eligible to participate in the interviews
Recruitment Centers must be National Clinical Trials Network (NCTN), National CancerInstitute Community Oncology Research Program (NCORP) or Minority Underserved (MU)-NCORP institutions
Recruitment Centers must have an active EHR and patient portal used in theoutpatient clinics which is common and accessible across all sites belonging to theRecruitment Center
Recruitment Centers must be willing to allow the S1904 study team access to thesite's application program interface (API) for integration of the study materials (standard educational materials and decision support tools) into the EHR and patientportal. (NOTE: Both Group 1 (control) and Group 2 (intervention) recruitment centersmay access the standard educational materials via the patient portal or uniformresource locator (URL)/website)
Recruitment centers must see at least 50 AH and/or LCIS patients per year
Recruitment centers must identify a lead principal investigator (PI) to facilitaterecruitment and retention of patients and healthcare providers and to participate inquarterly stakeholder meetings/conference calls
Recruitment centers must be willing to register at about 16 patients and 5healthcare providers to the study
Recruitment Centers must be willing to submit monthly screening logs to CUIMC
Providers must regularly see patients with AH or LCIS at an approved recruitmentcenter
Providers must be willing to provide informed consent and complete an onlinebaseline questionnaire
Providers who will register patients must be registered members of a CooperativeGroup
Providers who register patients to S1904 must be willing to see those same patientsfor their 6-month study visits, as the provider intervention tools require that the "treating investigator" as designated in OPEN and the provider at the 6-month studyvisit be the same
Exclusion
Exclusion Criteria:
Patients must not have a history of invasive breast cancer or ductal carcinoma insitu
Patients must not have prior or current use of selective estrogen receptormodulators (SERMs) or aromatase inhibitors (AIs)
NOTE: The following are approved SERMS and AIs, however, the study is notlimited to these.
SERMs: tamoxifen, raloxifene
AIs: anastrozole, exemestane, letrozole
Patients must not be currently taking hormone replacement therapy
Patients must not have a history of bilateral mastectomies or breast implants sincethe risk calculator is not applicable to these women
Patients must not be pregnant or lactating
Premenopausal patients must not have a history of thromboembolism, since it is acontraindication to tamoxifen. Tamoxifen is the only Food and Drug Administration (FDA)-approved drug for breast cancer chemoprevention among high-risk premenopausalwomen, whereas postmenopausal women are eligible for both SERMs and AIs
Study Design
Study Description
Connect with a study center
FHP Health Center-Guam
Tamuning, 96913
GuamSite Not Available
Kaiser Permanente-Deer Valley Medical Center
Antioch, California 94531
United StatesSite Not Available
UC Irvine Health Cancer Center-Newport
Costa Mesa, California 92627
United StatesSite Not Available
City of Hope Comprehensive Cancer Center
Duarte, California 91010
United StatesSite Not Available
Kaiser Permanente-Oakland
Oakland, California 94611
United StatesSite Not Available
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California 92868
United StatesSite Not Available
Kaiser Permanente Downtown Commons
Sacramento, California 95814
United StatesSite Not Available
Kaiser Permanente-South Sacramento
Sacramento, California 95823
United StatesSite Not Available
Kaiser San Rafael-Gallinas
San Rafael, California 94903
United StatesSite Not Available
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California 95051
United StatesSite Not Available
City of Hope South Pasadena
South Pasadena, California 91030
United StatesSite Not Available
Kaiser Permanente-South San Francisco
South San Francisco, California 94080
United StatesSite Not Available
Kaiser Permanente-Vallejo
Vallejo, California 94589
United StatesSite Not Available
Kaiser Permanente-Walnut Creek
Walnut Creek, California 94596
United StatesSite Not Available
Mount Sinai Comprehensive Cancer Center at Aventura
Aventura, Florida 33180
United StatesSite Not Available
Miami Cancer Institute
Miami, Florida 33176
United StatesSite Not Available
Mount Sinai Medical Center
Miami Beach, Florida 33140
United StatesSite Not Available
Miami Cancer Institute at Plantation
Plantation, Florida 33324
United StatesSite Not Available
Emory Saint Joseph's Hospital
Atlanta, Georgia 30342
United StatesSite Not Available
Emory University Hospital Midtown
Atlanta, Georgia 30308
United StatesSite Not Available
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia 30322
United StatesSite Not Available
Grady Health System
Atlanta, Georgia 30303
United StatesSite Not Available
Hawaii Cancer Care - Westridge
'Aiea, Hawaii 96701
United StatesSite Not Available
Pali Momi Medical Center
'Aiea, Hawaii 96701
United StatesSite Not Available
Queen's Cancer Center - Pearlridge
'Aiea, Hawaii 96701
United StatesSite Not Available
The Cancer Center of Hawaii-Pali Momi
'Aiea, Hawaii 96701
United StatesSite Not Available
The Queen's Medical Center - West Oahu
'Ewa Beach, Hawaii 96706
United StatesSite Not Available
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii 96813
United StatesSite Not Available
Hawaii Cancer Care Inc-Liliha
Honolulu, Hawaii 96817
United StatesSite Not Available
Hawaii Diagnostic Radiology Services LLC
Honolulu, Hawaii 96817
United StatesSite Not Available
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii 96826
United StatesSite Not Available
Kuakini Medical Center
Honolulu, Hawaii 96817
United StatesSite Not Available
Queen's Cancer Cenrer - POB I
Honolulu, Hawaii 96813
United StatesSite Not Available
Queen's Cancer Center - Kuakini
Honolulu, Hawaii 96817
United StatesSite Not Available
Queen's Medical Center
Honolulu, Hawaii 96813
United StatesSite Not Available
Straub Clinic and Hospital
Honolulu, Hawaii 96813
United StatesSite Not Available
The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii 96817
United StatesSite Not Available
University of Hawaii Cancer Center
Honolulu, Hawaii 96813
United StatesSite Not Available
Straub Medical Center - Kahului Clinic
Kahului, Hawaii 96732
United StatesSite Not Available
Castle Medical Center
Kailua, Hawaii 96734
United StatesSite Not Available
Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue, Hawaii 96766
United StatesSite Not Available
Loyola Center for Health at Burr Ridge
Burr Ridge, Illinois 60527
United StatesSite Not Available
Centralia Oncology Clinic
Centralia, Illinois 62801
United StatesSite Not Available
Advocate Illinois Masonic Medical Center
Chicago, Illinois 60657
United StatesSite Not Available
Carle at The Riverfront
Danville, Illinois 61832
United StatesSite Not Available
Carle on Vermilion
Danville, Illinois 61832
United StatesActive - Recruiting
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois 62526
United StatesSite Not Available
Carle Physician Group-Effingham
Effingham, Illinois 62401
United StatesSite Not Available
Crossroads Cancer Center
Effingham, Illinois 62401
United StatesSite Not Available
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
United StatesSite Not Available
Loyola University Medical Center
Maywood, Illinois 60153
United StatesSite Not Available
Cancer Care Center of O'Fallon
O'Fallon, Illinois 62269
United StatesSite Not Available
Advocate Lutheran General Hospital
Park Ridge, Illinois 60068
United StatesSite Not Available
Carle Cancer Center
Urbana, Illinois 61801
United StatesSite Not Available
The Carle Foundation Hospital
Urbana, Illinois 61801
United StatesSite Not Available
IU Health West Hospital
Avon, Indiana 46123
United StatesSite Not Available
IU Health North Hospital
Carmel, Indiana 46032
United StatesSite Not Available
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana 46202
United StatesSite Not Available
Sidney and Lois Eskenazi Hospital
Indianapolis, Indiana 46202
United StatesSite Not Available
Beverly Hospital
Beverly, Massachusetts 01915
United StatesSite Not Available
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United StatesSite Not Available
Lahey Hospital and Medical Center
Burlington, Massachusetts 01805
United StatesSite Not Available
Addison Gilbert Hospital
Gloucester, Massachusetts 01930
United StatesSite Not Available
Winchester Hospital
Winchester, Massachusetts 01890
United StatesSite Not Available
Borgess Medical Center
Kalamazoo, Michigan 49048
United StatesSite Not Available
West Michigan Cancer Center
Kalamazoo, Michigan 49007
United StatesSite Not Available
Mayo Clinic in Rochester
Rochester, Minnesota 55905
United StatesSite Not Available
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey 07920
United StatesSite Not Available
Memorial Sloan Kettering Monmouth
Middletown, New Jersey 07748
United StatesSite Not Available
Memorial Sloan Kettering Bergen
Montvale, New Jersey 07645
United StatesSite Not Available
Memorial Sloan Kettering Commack
Commack, New York 11725
United StatesSite Not Available
Memorial Sloan Kettering Westchester
Harrison, New York 10604
United StatesSite Not Available
Memorial Sloan Kettering Cancer Center
New York, New York 10065
United StatesSite Not Available
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York 10032
United StatesSite Not Available
Memorial Sloan Kettering Nassau
Uniondale, New York 11553
United StatesSite Not Available
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
United StatesSite Not Available
Cleveland Clinic Foundation
Cleveland, Ohio 44195
United StatesSite Not Available
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
United StatesSite Not Available
Good Samaritan Hospital
Corvallis, Oregon 97330
United StatesSite Not Available
Providence Portland Medical Center
Portland, Oregon 97213
United StatesSite Not Available
Providence Saint Vincent Medical Center
Portland, Oregon 97225
United StatesSite Not Available
Holy Redeemer Hospital and Medical Center
Meadowbrook, Pennsylvania 19046
United StatesSite Not Available
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
United StatesSite Not Available
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee 38017
United StatesSite Not Available
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee 38120
United StatesSite Not Available
Baptist Memorial Hospital for Women
Memphis, Tennessee 38120
United StatesSite Not Available
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
United StatesSite Not Available
Peninsula Cancer Institute-Newport News
Newport News, Virginia 23601
United StatesSite Not Available
VCU Massey Cancer Center at Stony Point
Richmond, Virginia 23235
United StatesSite Not Available
Virginia Cancer Institute
Richmond, Virginia 23229
United StatesSite Not Available
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia 23298
United StatesSite Not Available
VCU Community Memorial Health Center
South Hill, Virginia 23970
United StatesSite Not Available
Shenandoah Oncology PC
Winchester, Virginia 22601
United StatesSite Not Available
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire, Wisconsin 54701
United StatesSite Not Available
University of Wisconsin Carbone Cancer Center
Madison, Wisconsin 53792
United StatesSite Not Available
University of Wisconsin Hospital and Clinics
Madison, Wisconsin 53792
United StatesActive - Recruiting
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin 53215
United StatesSite Not Available
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241
United StatesSite Not Available
Aurora West Allis Medical Center
West Allis, Wisconsin 53227
United StatesSite Not Available
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