International Spontaneous Coronary Artery Dissection (SCAD) "iSCAD" Registry

Last updated: May 4, 2026
Sponsor: SCAD Alliance
Overall Status: Active - Not Recruiting

Phase

N/A

Condition

Hypercholesterolemia

Coronary Artery Disease

Chest Pain

Treatment

N/A

Clinical Study ID

NCT04496687
20190308
  • Ages > 18
  • All Genders

Study Summary

The aim of "iSCAD," the International Spontaneous Coronary Artery Dissection (SCAD) Registry, is to serve as an internationally collaborative, multicenter registry coordinated by an experienced and centralized coordinating center in an effort to increase the pace of participant recruitment, and thereby increase statistical power of studies related to SCAD.

The ultimate goal of iSCAD Registry is to facilitate the development of best practices and clinical guidelines for preventing SCAD or its recurrence. This observational study will be prospective and retrospective in its recruitment and will collect clinical information to better understand the natural history and prognosis for SCAD.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Participants with a new diagnosis of SCAD or a history of confirmed or suspected SCAD will be prospectively recruited from either:

  1. Inpatient wards of the enrolling medical centers during the acute presentation ofSCAD, or

  2. Outpatient cardiovascular clinics of enrolling medical centers.

Participants must be:

  • 18 years of age or older

  • Diagnosis of SCAD or history of SCAD based on coronary angiography, eithercatheter-based or coronary CTA

  • Suspected SCAD by coronary angiography

Exclusion

Exclusion Criteria:

  1. Coronary dissection in association with atherosclerosis or as a result of iatrogenicinjury

  2. Inability to provide informed consent

  3. Inability to complete study-related patient questionnaires

  4. Inability to understand and complete patient questionnaires independently

Study Design

Total Participants: 2000
Study Start date:
March 08, 2019
Estimated Completion Date:
December 31, 2026

Study Description

Spontaneous Coronary Artery Dissection (SCAD) is an under-diagnosed cause of acute coronary syndrome (ACS), myocardial infarction (MI) and sudden cardiac arrest. The inner lining of the coronary artery splits and allows blood to seep into the adjacent layer, forming a blockage (hematoma), or the artery continues to tear, creating a flap of tissue that blocks blood flow in the artery.

SCAD strikes generally healthy, younger individuals (average age 42) who do not have traditional cardiac risk factors. Warning signs of SCAD encompass the full range of ACS and MI symptoms, from vague to classic. The cause of SCAD is currently unknown and the psychosocial impact of SCAD is traumatizing. The work of the iSCAD Registry will encompass the physical and psychosocial study of SCAD.

Connect with a study center

  • Victor Chang Cardiac Research Institute

    Darlinghurst, New South Wales NSW 2010
    Australia

    Site Not Available

  • Cedars Sinai

    Los Angeles, California 90048
    United States

    Site Not Available

  • UCLA (University of California, Los Angeles)

    Los Angeles, California 93003
    United States

    Site Not Available

  • Kaiser Permanente Northern California

    San Francisco, California 94115
    United States

    Site Not Available

  • University of Colorado

    Aurora, Colorado 80045
    United States

    Site Not Available

  • Hartford Hospital

    Hartford, Connecticut 06106
    United States

    Site Not Available

  • University of South Florida

    Tampa, Florida 33602
    United States

    Site Not Available

  • Emory Healthcare System

    Atlanta, Georgia 30308
    United States

    Site Not Available

  • Northwestern Medicine

    Chicago, Illinois 60611
    United States

    Site Not Available

  • University of Kentucky

    Lexington, Kentucky 40508
    United States

    Site Not Available

  • Johns Hopkins

    Baltimore, Maryland 21224
    United States

    Site Not Available

  • Massachusetts General Hospital

    Boston, Massachusetts 02114-2696
    United States

    Site Not Available

  • St. Luke's Mid America

    Kansas City, Missouri 64111
    United States

    Site Not Available

  • Washington University

    Saint Louis, Missouri 63110
    United States

    Site Not Available

  • Washington University

    St Louis, Missouri 63110
    United States

    Site Not Available

  • Dartmouth-Hitchcock

    Lebanon, New Hampshire 03756
    United States

    Site Not Available

  • Catholic Medical Center

    Manchester, New Hampshire 03102
    United States

    Site Not Available

  • Columbia University Medical Center

    New York, New York 10032
    United States

    Site Not Available

  • Mount Sinai

    New York, New York 10029-6574
    United States

    Site Not Available

  • Atrium Health Sanger Heart and Vascular Institute

    Charlotte, North Carolina 28204
    United States

    Site Not Available

  • University Hospitals--Case Western

    Cleveland, Ohio 44106
    United States

    Site Not Available

  • Oklahoma Heart

    Oklahoma City, Oklahoma 73120
    United States

    Site Not Available

  • Providence

    Portland, Oregon 97225
    United States

    Site Not Available

  • University of Pennsylvania

    Philadelphia, Pennsylvania 19104
    United States

    Site Not Available

  • Allegheny General Hospital, Allegheny Health Network

    Pittsburgh, Pennsylvania 15212
    United States

    Site Not Available

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania 15213
    United States

    Site Not Available

  • Vanderbilt University Medical Center

    Nashville, Tennessee 37232
    United States

    Site Not Available

  • UT Southwestern

    Dallas, Texas 75390
    United States

    Site Not Available

  • Intermountain

    Murray, Utah 84107
    United States

    Site Not Available

  • University of Virginia

    Charlottesville, Virginia 22908
    United States

    Site Not Available

  • Inova Heart & Vascular Institute

    Fairfax, Virginia 22031
    United States

    Site Not Available

  • University of Washington Medicine

    Seattle, Washington 98195
    United States

    Site Not Available

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