Effects of Ecopipam or Placebo in Adults With Stuttering (Speak Freely)

Inclusion Criteria:

• Able to read and write in English and provide informed consent
• 18 years or older of age at screening
• Weighs >= 45 kg (~99 lbs)
• Satisfies DSM-5 criteria for childhood onset fluency disorder
• History of stuttering for >=2 years with onset consistent to developmental in nature
• Must meet an allowed severity of stuttering at screening and baseline, scored by acentral rater
• Completed an adequate course of speech therapy
• Has a qualifying IOS or Android smartphone
• Must discontinue all medications used to treat stuttering for at least 14 days priorto screening
• Sexually active females of child bearing potential must be using effectivecontraception during and 30 days after participation
• Sexually active males must use a double barrier method of contraception during and 30days after participation

Exclusion Criteria:

• Stuttering is related to a known neurological cause
• Initiation of new behavioral therapies for stuttering within 10 weeks prior tobaseline
• Unstable medical illness or clinically significant abnormalities on screeningtests/exams
• At a significant risk of committing suicide
• Are pregnant or lactating
• Positive urine drug screen
• Lifetime history of major depressive episode
• History of seizures
• Have been previously treated with ecopipam
• Unstable use of medications prior to screening
• Use of prohibited medications or need for medications which would have unfavorableinteractions with ecopipam
• Not suitable for study in the opinion of the Principle Investigator