Anxiety and Depression Disorder in Patient Treated With rTPA for Mangment of Acute Ischemic Stroke

Last updated: July 22, 2020
Sponsor: Assiut University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Depression

Cerebral Ischemia

Panic Disorders

Treatment

N/A

Clinical Study ID

NCT04484558
01001297992
  • Ages 40-75
  • All Genders

Study Summary

In fact theWorld Health Organization estimates that 2-3% in general populations of countries across the world tend to be affected by severe mental disorders (1) Thrombolytic therapy seems to be of great importance in achieving better quality of life in ischemic stroke patients who respond to this therapy(rTPA).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. age more than 40.

  2. None of the pt had history of other psychiatric illness.

  3. male and female.

Exclusion

Exclusion Criteria:

  • 1-smoker. 2-substance abuser or dependence. 3-History of other psychiatric illness. 4-History of other neurological illness.

Study Design

Total Participants: 40
Study Start date:
January 01, 2020
Estimated Completion Date:
December 01, 2021

Study Description

There is a substantial body of evidenc suggesting a strong relation between neurotrophic factors and depression and anxiety pathogenesis (2,8) Brain-derived neurotrophic factor (BDNF), a member of the neurotrophic family known to regulate neuronal plasticity and survival , may play an important role in the pathophysiology of depression and anxiety (3,9).

Different studies indicated patients who were exposed to traumatic events have anxiety comorbidity and lower levels of serum BDNF compared to those without a history of traumatic events (4) .

BDNF has an antidepressant and anxiolytic effect which suggest that BDNF is implicated in the regulation of anxiety-related behaviors. which leads to a valine-to-methionine change in the proBDNF protein, was associated with lower activity-dependent secretion of BDNF (5)and has been implicated with increased susceptibility to neuropsychiatric disorders including depression, anxiety-related dysfunction, and bipolar disorder , all these studies suggest that BDNF is likely to be an important etiological factor in memory, depression and anxiety disorders (6,10).

BDNF arises from a precursor, proBDNF, which is cleaved to produce the mature protein through the tissue plasminogen activator (tPA) pathway, and represents one mechanism that can regulate the action of BDNFarises from a precursor, proBDNF, which is cleaved to produce the mature protein through the tissue plasminogen activator (tPA) pathway, and represents one mechanism that can regulate the action of BDNF (7).

The purpose of this study is to examine the quality of life after stroke of patients treated with thrombolysis .

Connect with a study center

  • Assiut university

    Assiut, 17111
    Egypt

    Active - Recruiting

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