Deep Transcranial Magnetic Stimulation for the Treatment of Treatment Resistance Schizophrenia

Phase

N/A

Condition

Tourette's Syndrome

Mood Disorders

Schizotypal Personality Disorder (Spd)

Treatment

N/A

Clinical Study ID

NCT04478032

20194Y0037

Ages 18-60
All Genders

Study Summary

Based on the hypothesis that low-frequency deep transcranial magnetic stimulation(dTMS) on anterior cingulate cortex （ACC） could down-regulate the glutamate level of ACC and regulate the acc-related functional network in patients with treatment resistance schizophrenia,this research plan to utilise multimodal functional magnetic imaging method(including structural MRI,resting-state functional magnetic resonance imaging and 1H-MRS) to investigate therapeutic efficacy of low-frequency deep transcranial magnetic stimulation on SZ patients symptoms,as well as to elucidate the correlation between treatment effects and glutamate level of ACC

Eligibility Criteria

Inclusion

Inclusion Criteria:

Patients with schizophrenia who meet the dsm-5 diagnostic criteria
Aged from 18 to 60
After 4 weeks of treatment with a sufficient dose of an antipsychotic (equivalent doseof 400 ~ 600 mg/ day chlorpromazine (CPZ)), no clinical improvement was achieved (atleast two items in PANSS scale P1,P2,P3,N1,N4,N6,G5 and G9 ≥4 points, or cgi-s ≥4points)
Right-handedness, normal hearing, visual acuity or corrected visual acuity
Written informed consent of the patient and his/her family

Exclusion

Exclusion Criteria:

Patients who are currently taking clozapine or who have failed to respond to a fullcourse of treatment with clozapine
Current or past neurological illness,severe physical illness,substance abuse oraddiction,alcohol dependence,mental retardation,pregnancy or lactation,extremeagitation, stupor, negative suicide,or those who can not cooperate
A history of MECT within 6 months,or those with contraindications to MRI,rTMS
Medically unstable for at least 1 month (PANSS score fluctuation>10%)

Study Design

July 05, 2020

December 30, 2022

Study Description

This study includes 20 treatment resistance schizophrenia patients and 20 healthy controls.This study will investigate 1)abnormalities of the glutamate level of ACC in patients with schizophrenia compared to healthy controls by using 1H-MRS technique. 2)potential modulation effects of deep transcranial magnetic stimulation(dTMS) on anterior cingulate cortex function of patients with schizophrenia. 3)the therapeutic efficacy of dTMS on cognitive impairments and other psychotic symptoms of patients with schizophrenia by adopting cognitive function and psychotic symptoms evaluation,as well as to explore the optimal dTMS treatment pattern on cognitive function.

Connect with a study center

Shanghai Mental Health Center
Shanghai, Shanghai 200030
China
Active - Recruiting

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