Cognitive Training in Stroke Rehabilitation

Last updated: January 27, 2025
Sponsor: Weill Medical College of Cornell University
Overall Status: Terminated

Phase

N/A

Condition

Memory Loss

Mental Disability

Memory Problems

Treatment

ASCEND-I

Clinical Study ID

NCT04472351
20-05022146
  • Ages 30-89
  • All Genders

Study Summary

This is a randomized, controlled pilot study to evaluate the efficacy of "ASCEND-I" (A Strategy and Computer-based intervention to ENhance Daily cognitive functioning after stroke - Inpatient), an inpatient intervention that combines computer-based cognitive training and coaching of cognitive strategies to improve working memory (WM) and related executive functions in individuals with stroke. The investigators hypothesize that relative to an "enhanced usual care" control condition, ASCEND will be associated with improvements in WM. The investigators also hypothesize that measures of baseline brain connectivity (assessed via participants' routine clinical magnetic resonance imaging scans) will predict response to ASCEND-I.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Patient admitted for a stroke and accepted to acute inpatient rehabilitation atNYP-Weill Cornell.

  2. Age 30-89

  3. English speaking

  4. Ability to comprehend sufficiently to participate in the treatment

  5. Mild-moderate cognitive impairment as determined by a standard of care cognitivescreening tools administered by occupational therapists (e.g., Montreal CognitiveAssessment, Symbol-Digit Modalities Test, or other clinical standard of careinstrument). We will review subjects' most recent cognitive assessment administeredby OT (Occupational Therapists) and available in the EMR (Electronic MedicalRecords) to determine eligibility.

  6. Willingness to participate in full study duration

  7. Physically able to operate a computer keyboard, tablet/iPad, and mouse.

Exclusion

Exclusion Criteria:

  1. History of other neurologic disorder (e.g., Parkinson's disease, Multiple Sclerosis,Alzheimer's disease, brain tumor). History of previous stroke(s) will not beexclusionary as long as the subject does not self-report having lasting/persistentcognitive impairment from the prior stroke.

  2. History of severe mental illness (e.g., schizophrenia, psychosis) or substance usedisorder, recent history (in the past year) of alcohol/substance use disorder orsymptoms of psychosis. Note that the presence of post-stroke depression will not begrounds for exclusion.

  3. History of dementia

  4. Moderate-severe hemispatial neglect as determined by OT evaluation

  5. Any factor that in the investigator's opinion is likely to compromise the subject'sability to participate in the study, including evidence that the subject may notunderstand and/or adhere to study requirements

Study Design

Total Participants: 27
Treatment Group(s): 1
Primary Treatment: ASCEND-I
Phase:
Study Start date:
January 12, 2021
Estimated Completion Date:
September 15, 2022

Connect with a study center

  • Weill Cornell Medicine

    New York, New York 10065
    United States

    Site Not Available

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