Restorative proctectomy is increasingly being performed for rectal cancer, allowing
patients to avoid permanent colostomy. Low Anterior Resection Syndrome (LARS) refers to a
constellation of bowel symptoms including frequency, urgency, incontinence, and
clustering of bowel movements, that can affect up to 70 to 90% of patients following
restorative proctectomy. Symptoms can last up to 15 years after resection. Currently,
there is no standard treatment for LARS and management is symptom-based and reactive,
rather than proactive. A recent focus group conducted at our institution among LARS
patients and caregivers showed that people living with LARS experience anxiety and
isolation due to their symptoms.
Peer support could be an important psychosocial intervention for people living with LARS,
helping them normalize and validate their experience. Peer support refers to a supportive
relationship between individuals who share common experiences or face similar challenges.
This approach has been associated with positive physical and mental health outcomes for
several patient populations. Our research group conducted a comprehensive review of
online health information for patients with LARS, and demonstrated that existing online
resources were generally of poor quality and lacked important content. With this
knowledge, we created a LARS educational booklet and developed an online app containing
LARS educational material and an interactive forum for online peer support. We are now in
an optimal position to rigorously test the potential effects of this initiative on
patient-centered outcomes.
This study is a multicenter, randomized, assessor-blind, parallel-groups, pragmatic trial
involving patients from 5 large colorectal surgery practices (Jewish General Hospital,
McGill University Health Centre-Montreal, QC; Toronto Western Hospital, Mount Sinai
Hospital- Toronto, ON; Saint Paul's Hospital-Vancouver, BC). Participants will be
randomized into the intervention group, who will have access to the online peer support
app, and the control group who will only receive a LARS patient educational booklet.
Trained peer support mentors will moderate discussion in the peer support forum, which
will also be monitored daily by expert health care professionals. Data regarding patient
demographics, disease and treatment characteristics will be obtained via hospital chart
review. The primary outcome will be health- related quality of life at 6 months.
Secondary outcomes will be patient activation and bowel function. We hypothesize that
availability of this app (consisting of LARS information, a closed forum for discussion
among peers and trained peer support mentors) improves health-related quality of life
when compared to the comparison group.
Given the significant numbers of patients who suffer from LARS symptoms following
restorative proctectomy and the potential chronic nature of their symptoms, this RCT has
the potential to contribute important knowledge to support patient-centered care of
rectal cancer survivors. The technology addressed in this study (a mobile app for
information and online peer support) is readily accessible and can be relatively easily
implemented across large range of geographic jurisdictions and surgical settings.