Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy

Last updated: February 27, 2024
Sponsor: Oregon Health and Science University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Progressive Supranuclear Palsy

Cataplexy

Treatment

Repetitive transcranial magnetic stimulation (rTMS)

Clinical Study ID

NCT04468932
STUDY0020341
P2CHD086844
KL2TR002370
K23NS121402
  • Ages 40-85
  • All Genders

Study Summary

The objective of this proposal is to investigate the effect of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) on motor control in progressive supranuclear (PSP). The central hypothesis is that augmenting cerebellar inhibition via cerebellar rTMS will decrease postural instability in patients with PSP. We will use functional near infrared spectroscopy (fNIRS) to examine changes in motor and premotor cortical activity after cerebellar rTMS.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • probable or possible PSP by the revised MDS PSP Criteria (Hoglinger 2017)
  • age 40-85 at time of screening
  • ability to understand and cooperate with simple instructions in English
  • ability to read at 6th grade reading level in English
  • ability to stand unassisted for at least 30 seconds and to be able walk independentlywith a walker
  • ability to refrain from new physical and speech therapy programs for the duration ofthe study
  • ability to remain on stable doses of any cholinergic, dopaminergic, serotonergicsedative or NMDA receptor antagonists for the duration of the study
  • females of child-bearing age must perform a urine pregnancy test and be on reliablebirth control during the course of the study

Exclusion

Exclusion Criteria:

  • other significant neurological or vestibular disorders
  • presence of electrically, magnetically or mechanically activated implants or historyof injurious metal exposure in eyes, head, or body

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: Repetitive transcranial magnetic stimulation (rTMS)
Phase:
Study Start date:
January 17, 2020
Estimated Completion Date:
April 20, 2027

Connect with a study center

  • Oregon Health & Science University

    Portland, Oregon 97239
    United States

    Active - Recruiting

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