DEXTENZA for the Treatment of Postoperative Pain and Inflammation Following Vitreo-retinal Surgery

Inclusion Criteria:

• Any adult patient age 18-99 years who is planned to undergo vitreo-retinal surgery (pars plana vitrectomy with or without scleral buckle).
• If both eyes are involved, both eyes would be eligible for the study.
• Willing and able to comply with clinic visits and study related procedures.
• Willing and able to sign the informed consent form.

Exclusion Criteria:

• Patients under age 18.
• Patients who are pregnant (must be ruled out in women of child-bearing age withpregnancy test).
• Active infectious ocular or systemic disease.
• Patients with active infectious ocular or extraocular disease.
• Patients actively treated with local or systemic immunosuppression
• Use of the following anti-inflammatory or immunomodulating agents (e.g., cyclosporine)systemically, or in the study eye, for the duration of the study (excludinginhalants). Washout periods for medications prior to surgery are as follows:
• Systemic corticosteroids - 2 weeks (see exception 5c)
• Systemic NSAID over 375 mg per day - 2 weeks
• Periocular/intraocular injection of any corticosteroid solution - 4 weeks (seeexception 5b)
• Corticosteroid depot/implant in the study eye - 2 months
• Topical ocular corticosteroid - 7 days
• Topical ocular NSAID - 7 days
• Intraoperatively used intraocular steroid (i.e. intravitreal triamcinolone, that isused to transiently highlight the vitreous and removed during vitrectomy) ispermissible in study eye.
• Intraoperatively or perioperatively used systemic steroid for the purpose of generalanesthesia (as administered by the treating anesthesiologist) is permissible.
• Patients with systemic illness involving abnormalities of thehypothalamic-pituitary-adrenal axis; patients with primary adrenocorticalinsufficiency or adrenocortical hyperfunction.
• Patients with known hypersensitivity to Dexamethasone.
• Patients with uncontrolled glaucoma.
• Patients with severe disease that warrants critical attention, deemed unsafe for thestudy by the investigator.