Observational Study for the Evaluation of Incidence of Familial AML/MDSs in Patients With Myeloid Neoplasms

Last updated: April 9, 2024
Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto
Overall Status: Active - Recruiting

Phase

N/A

Condition

Acute Myeloid Leukemia

Leukemia

White Cell Disorders

Treatment

N/A

Clinical Study ID

NCT04460950
AML2120
  • Ages > 18
  • All Genders

Study Summary

Observational study aimed at evaluating the incidence of familial AML/MDSs in patients with de novo MDSs or AML with almost one relative affected by hematologic neoplasms and/or other cancers at young age (< 40 years)

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patient age > 18 years old
  • Diagnosis of AML or MDSs from January 2014 to December 2022
  • Suspected familiarity for myeloid neoplasm: at least one family member of first orsecond degree affected by myeloid neoplasm or other hematological malignancy, or bysolid tumors with onset at age < 40 years or presence of signs, symptoms or laboratorytests compatible with one of the known syndromes with germinal susceptibility toAML/MDSs
  • Signed written informed consent according to ICH/EU/GCP and national local laws.

Exclusion

Exclusion Criteria:

  • none

Study Design

Total Participants: 237
Study Start date:
December 16, 2020
Estimated Completion Date:
March 31, 2025

Study Description

This is a multicenter, retrospective and prospective, observational study aims to collect clinical information on patients with familial AML/MDSs from January 2014 to December 2022. No intervention is expected.

The purpose of this study is to identify and characterize the patients with familial MDSs or AML (i.e. with relatives affected by hematologic neoplasms and/or other cancers at young age (< 40 years)) or presence of signs, symptoms or laboratory tests compatible with one of the known syndromes with germinal susceptibility to AML/MDSs.

In order to estimate the incidence of familial AML/MDSs, a survey will be sent every year to all participating sites to collect only the number of the all diagnosis of AML/MDS. All patients will be followed until December 2023 in order to have at least 1 year of observation.

Connect with a study center

  • Aon Ss. Antonio E Biagio E C. Arrigo - Alessandria - Soc Ematologia

    Alessandria,
    Italy

    Active - Recruiting

  • Aou Ospedali Riuniti "Umberto I - G.M. Lancisi - G. Salesi"- Ancona - Sod Clinica Ematologica

    Ancona,
    Italy

    Active - Recruiting

  • Ao Di Rilievo Nazionale E Di Alta Specialità "San Giuseppe Moscati" - Avellino - Uoc Ematologia Con Unità Di Trapianto

    Avellino,
    Italy

    Active - Recruiting

  • Asl Caserta, Presidio Ospedaliero S.G.Moscati - Aversa - Uo Oncoematologia

    Aversa,
    Italy

    Active - Recruiting

  • Aou Di Bologna - Policlinico S. Orsola-Malpighi - Uoc Ematologia

    Bologna,
    Italy

    Active - Recruiting

  • Asst Degli Spedali Civili Di Brescia - Ssvd Centro Trapianti Midollo Per Adulti - Cattedra Di Ematologia

    Brescia,
    Italy

    Active - Recruiting

  • Asst Degli Spedali Civili Di Brescia - Uo Ematologia

    Brescia,
    Italy

    Active - Recruiting

  • Ao Brotzu, Presidio Ospedaliero A. Businco - Cagliari - Sc Ematologia E Ctmo

    Cagliari,
    Italy

    Active - Recruiting

  • Aou Ospedali Riuniti - Foggia - Uoc Ematologia

    Foggia,
    Italy

    Active - Recruiting

  • Asl Lecce, Ospedale 'V. Fazzi' - Uo Ematologia

    Lecce,
    Italy

    Active - Recruiting

  • Ao Ospedali Riuniti "Papardo Piemonte" - Po Papardo - Messina - Sc Ematologia

    Messina,
    Italy

    Active - Recruiting

  • Asst Grande Ospedale Metropolitano Niguarda - Milano - Sc Ematologia

    Milano,
    Italy

    Active - Recruiting

  • Fondazione Irccs Ca' Granda, Ospedale Maggiore Policlinico - Milano - Ematologia - Padiglione Marcora

    Milano,
    Italy

    Active - Recruiting

  • Aou San Luigi Gonzaga - Orbassano - Scdu Ematologia Generale E Oncoematologia

    Orbassano,
    Italy

    Active - Recruiting

  • Asl Salerno, Presidio Ospedaliero Tortora Pagani - Ematologia

    Pagani,
    Italy

    Active - Recruiting

  • Aou Policlinico P. Giaccone - Palermo - Uo Ematologia

    Palermo,
    Italy

    Active - Recruiting

  • Aou Di Parma - Sc Ematologia E Centro Trapianti Midollo Osseo

    Parma,
    Italy

    Active - Recruiting

  • Ao Di Perugia, Ospedale S. Maria Della Misericordia - Ematologia E Trapianto Midollo Osseo

    Perugia,
    Italy

    Active - Recruiting

  • Aou Pisana - Uo Ematologia Universitaria

    Pisa,
    Italy

    Active - Recruiting

  • Ausl Di Reggio Emilia - Arcispedale Santa Maria Nuova, Irccs - Sc Ematologia

    Reggio Emilia,
    Italy

    Active - Recruiting

  • Ausl Della Romagna, Ospedale "Infermi" - Rimini - Uo Ematologia

    Rimini,
    Italy

    Active - Recruiting

  • Asl Roma 2, Ospedale S. Eugenio- Ospedale S.Eugenio - Uoc Ematologia

    Roma,
    Italy

    Active - Recruiting

  • Fondazione Policlinico Universitario Agostino Gemelli Irccs - Roma - Area Ematologica

    Roma,
    Italy

    Active - Recruiting

  • Ente Ecclesiastico Casa Sollievo Della Sofferenza - San Giovanni Rotondo - Ematologia

    San Giovanni Rotondo,
    Italy

    Active - Recruiting

  • Aou Di Sassari - Cliniche Universitarie - Stabilimento Cliniche Di San Pietro - Uoc Ematologia

    Sassari,
    Italy

    Active - Recruiting

  • Aou Città Della Salute E Della Scienza, Ospedale S. Giovanni Battista Molinette - Torino - Sc Ematologia - Università Degli Studi Di Torino

    Torino,
    Italy

    Active - Recruiting

  • Asui Di Udine - Presidio Ospedaliero "Santa Maria Della Misericordia" - Clinica Ematologica

    Udine,
    Italy

    Active - Recruiting

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