Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension

Last updated: March 20, 2026
Sponsor: Duke University
Overall Status: Active - Recruiting

Phase

4

Condition

Circulation Disorders

Williams Syndrome

Stress

Treatment

Mepivacaine

Saline

Perifemoral Injection of Local Anesthetic

Clinical Study ID

NCT04454203
Pro00104144
  • Ages 18-75
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The goal of this prospective randomized double-blind study is to determine if an ultrasound guided peri-arterial injection of local anesthetic (LA) superomedially the femoral artery via peripheral nerve catheter reverses ischemic hypertension associated with prolonged lower extremity tourniquet time.

Eligibility Criteria

Inclusion

Inclusion Criteria:

Patients that will be included in the study are English speaking 18-75 year old ASA 1-3 patients undergoing total ankle arthroplasty.

Exclusion

Exclusion Criteria:

  1. ASA 4 or 5

  2. Diagnosis of chronic pain

  3. Daily chronic opioid use (over 3 months of continuous opioid use).

  4. Inability to communicate pain scores or need for analgesia.

  5. Infection at the site of block placement

  6. Age under 18 years old or greater than 75 years old

  7. Pregnant women (as determined by standard of care day-of surgery urine bHCG)

  8. Intolerance/allergy to local anesthetics

  9. Weight <50 kg

  10. Suspected, or known addiction to or abuse of illicit drug(s), prescriptionmedicine(s), or alcohol within the past 2 years.

  11. Uncontrolled anxiety, schizophrenia, or other psychiatric disorder that, in theopinion of the investigator, may interfere with study assessments or compliance.

  12. Current or historical evidence of any clinically significant disease or conditionthat, in the opinion of the investigator, may increase the risk of surgery orcomplicate the subject's postoperative course

Study Design

Total Participants: 40
Treatment Group(s): 3
Primary Treatment: Mepivacaine
Phase: 4
Study Start date:
February 05, 2021
Estimated Completion Date:
February 03, 2027

Study Description

This is a research study to find out if injection of numbing medication by the large artery going down your leg will improve high blood pressure caused by the tourniquet.

Depending on whether you enroll in this study, you may receive an injection of local anesthetic (numbing medication) or saline (salt water) by your femoral artery (the large artery going down your leg). This is to see how this injection impacts your blood pressure during surgery as the surgeons use a tourniquet (device that squeezes your leg) to help decrease the bleeding during surgery. Oftentimes the tourniquet causes your blood pressure to go up, but the numbing medication may help return your blood pressure close to its normal level. The rest of your anesthesia care, including other nerve blocks and general anesthetic, will be the same as it would be without participating in the study. You will be enrolled in this study for 24 hours.

Connect with a study center

  • Duke University Hospital

    Durham, North Carolina 27710
    United States

    Active - Recruiting

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