Tablet-based Cognitive Training

Last updated: January 8, 2025
Sponsor: University of Bern
Overall Status: Completed

Phase

N/A

Condition

Dementia

Alzheimer's Disease

Mental Disability

Treatment

Computerized Cognitive Training

Documentaries with delayed Computerized Cognitive Training

Clinical Study ID

NCT04452864
2020-00630
  • Ages 60-85
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Today the therapy options for dementia due to Alzheimer's disease (AD) are limited. One recommended intervention is cognitive stimulation. We try to develop serious games as a further treatment option, also usable in pre-dementia as well as early stages of dementia and for a long period of time.

The main objective of this study is to test, if the computerized-cognitive training (CCT) is able to improve the performance in a score quantifying an "AD-specific" component score. Additionally, the neurobiological effects of the training are investigated.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Clinical diagnosis of Alzheimer's Disease

  • Patients with increased risk for developing dementia

  • Must be able to give their consent

Exclusion

Exclusion Criteria:

  • Contra-indications for MRI scanning

  • Substance abuse

  • Severe medical conditions

Study Design

Total Participants: 162
Treatment Group(s): 2
Primary Treatment: Computerized Cognitive Training
Phase:
Study Start date:
July 01, 2020
Estimated Completion Date:
October 31, 2024

Study Description

The study intervention consists of a computer-based cognitive training, targeting the cognitive domains mostly affected by AD. This training will be performed for three months (each day for 20 minutes). After three months the intervention group will continue the training at home for six months and meet monthly for group sessions (i.e. booster sessions) on site.

Primary endpoint will be the change in an "AD-specific" component score, quantified by episodic memory, semantic memory and visuospatial abilities. Secondary endpoints are changes in task related brain networks and changes in resting state networks.

Connect with a study center

  • University Hospital of Old Age Psychiatry and Psychotherapy

    Bern, 3000
    Switzerland

    Site Not Available

  • Memory Clinic Zentralschweiz

    Luzern, 6000
    Switzerland

    Site Not Available

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