Physiologic MR Imaging of Salivary Gland Tumors

Last updated: February 5, 2025
Sponsor: Abramson Cancer Center at Penn Medicine
Overall Status: Active - Recruiting

Phase

N/A

Condition

Saliva And Salivary Gland Dysfunction

Treatment

MRI

Clinical Study ID

NCT04452162
25319
834242
  • Ages > 18
  • All Genders

Study Summary

The goal of this study is to use advanced Magnetic Resonance Imaging (MRI) techniques to help identify the difference between cancerous and non-cancerous salivary gland tumors for improving treatment strategies and to aid in the prediction of disease progression.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Possess a salivary gland lesion of 1cm3 size

  • Have no prior history of treatment for salivary gland lesion

Exclusion

Exclusion Criteria:

  • Has any prior history of cancer other than SGT

  • Has any MRI contra-indications

  • Has a history of known renal disease.

  • Has history of prior radiation to head and neck region

  • Is pregnant

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: MRI
Phase:
Study Start date:
August 25, 2020
Estimated Completion Date:
June 30, 2025

Study Description

The goal of this proposed study is to investigate the potential utility of combined analysis of parameters (Ktrans, ti and ADC) in discriminating benign from malignant salivary glands tumors (SGTs). A total of 30 treatment naïve patients suspicious of SGT as observed on clinical evaluation and prior routine CT, MRI, Ultrasound, FNAC and/or PET will undergo 3T MRI. The MRI protocol will include acquisition of anatomical images with and without contrast agent injection, diffusion imaging and dynamic contrast enhanced-MRI.

Connect with a study center

  • Hospital of the University of Pennsylvania

    Philadelphia, Pennsylvania 19104
    United States

    Active - Recruiting

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