The Effect of Eplerenone on the Evolution of Vasculopathy in Renal Transplant Patients.

Inclusion Criteria:

• Men or women ≥ 50 years of age;

• Patient who had a kidney transplant at least one year prior to inclusion;

• Patient on cyclosporine;

• Patient whose clinical-biological state has been stable for at least 3 months: nochange in treatment with an impact on blood pressure (excluding immunosuppressivedrug) for 3 months, no acute rejection diagnosed within 3 months;

• Patient with a glomerular filtration rate estimated according to the formula CKD-EPI ≥30mL/min/1.73m2;

• Patient with a peripheral PAS≥110mmHg, irrespective of the presence or not of anantihypertensive therapy (including ACE inhibitors or sartan) ;

• Patient with signed informed consent;

• Patient affiliated with or beneficiary of a social security system.

Exclusion Criteria:

• Patient with documented kalemia ≥ 5mmol/L in the last 15 days;

• Patient undergoing mineralocorticoid receptor antagonism or with a formal indicationto receive this treatment;

• Bicarbonate blood level <20mmol/L with or without documented supplementation in thelast 15 days.

• Indication for a combination of ACE inhibitor and sartan (each of which isauthorized separately);

• Patient under another potassium sparing diuretics;

• Patient under digoxine;

• Sodium polystyrene sulfonate contraindication;

• Known hypersensitivity or allergy to eplerenone and its excipients;

• Patient with severe hepatic impairment (Child-Pugh Class C);

• Patient under CYP3A4 inhibitor;

• know intolerance to Galactose, a Lapp lactase deficiency or galactose malabsorptionsyndrome;

• Patient participating in other interventional research;

• Woman with a desire of pregnancy within 15 months;

• Woman of childbearing age without effective contraception;

• Persons referred to in Articles L. 1121-5, L. 1121-7 and L1121-8 of the PublicHealth Code :

• Pregnant women, parturient women or nursing mothers ;

• Adult person subject to a legal protection measure (guardianship, curator, judicialsafeguard);

• Adults person who is unable to give consent and who is not subject to a legalprotection measure;

• Persons deprived of their liberty by a judicial or administrative decision;

• Persons subject to psychiatric care pursuant to articles L. 3212-1 and L. 3213-1.