Vitamin D Regulates the Expression of Glucocorticoid Receptors in Blood of Severe Asthmatic Patients

Last updated: June 19, 2020
Sponsor: Dubai Health Authority
Overall Status: Completed

Phase

N/A

Condition

Asthma

Treatment

N/A

Clinical Study ID

NCT04443387
MRC-04/2012_06
  • Ages 18-65
  • All Genders

Study Summary

Vitamin D (VitD) deficiency is a significant public health concern in many areas around the globe which has been associated with many immune-mediated diseases, including asthma. Severe asthma has been linked with a decreased glucocorticoid receptors (GR) ratio (GR-α/ GR-β ratio), indicating steroid hyporesponsiveness. Using combined in silico and in vivo approaches, aimed to explore the immunomodulatory effect of VitD on asthmatic patients diagnosed with hypovitaminosis D.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Diagnosis of asthma

  • age group between 18 and 65 years

  • low level of 25-hydroxyvitamin D3 (25 D3) level less than 20ng/mL

Exclusion

Exclusion Criteria:

  • smoker patients

  • less than 18 years old

  • patient on Vitamin D supplementation already

Study Design

Total Participants: 45
Study Start date:
April 01, 2012
Estimated Completion Date:
December 31, 2014

Study Description

Vitamin D (VitD) deficiency is a significant public health concern in many areas around the globe which has been associated with many immune-mediated diseases, including asthma. Severe asthma has been linked with a decreased glucocorticoid receptors (GR) ratio (GR-α/ GR-β ratio), indicating steroid hyporesponsiveness. Using combined in silico and in vivo approaches, the investigators aimed to explore the immunomodulatory effect of VitD on asthmatic patients diagnosed with hypovitaminosis D. Methods: In silico tools were used to identify the regulatory effect of VitD supplementation on GR genes. The investigators measured the expression levels of GR-α and the inactive isoform, GR-β, in the blood of adult asthmatics diagnosed with hypovitaminosis D before and after VitD supplementation. Moreover, the blood levels of inflammatory cytokines associated with asthma severity were determined.