Electroencephalography (EEG) Predictors of Transcranial Direct Current Stimulation (tDCS) in Obsessive-Compulsive Disorder (OCD)

Last updated: May 12, 2025
Sponsor: Shanghai Mental Health Center
Overall Status: Completed

Phase

N/A

Condition

Obsessive-compulsive Disorder

Kleptomania

Anxiety Disorders

Treatment

High-Definition transcranial direct current stimulation

Clinical Study ID

NCT04426773
SMHC-OCD-006
  • Ages 18-50
  • All Genders

Study Summary

This study is designed to find Electroencephalogram (EEG) biomarkers to predict transcranial direct current stimulation (tDCS) response in obsessive-compulsive disorder.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • age: 18-50 years old;

  • DSM-5 criteria for OCD;

  • Y-BOCS total score > or = 16

  • >or＝9 years education

Exclusion

Exclusion Criteria:

  • any additional current psychiatric comorbidity

  • The inability to receive tDCS because of metallic implants, or history ofseizures，history of head injury, or history of neurosurgery.

  • Participants with claustrophobic, heart pacemaker, mechanical heart valve,mechanical implant such as an aneurysm clip, hip replacement, or any other pieces ofmetal that have accidentally entered their body.

  • Any current significant medical condition.

  • serious suicide risk

Study Design

Total Participants: 40
Treatment Group(s): 1
Primary Treatment: High-Definition transcranial direct current stimulation
Phase:
Study Start date:
July 01, 2020
Estimated Completion Date:
May 01, 2025

Study Description

The purpose of this study is to explore resting state electroencephalography and transcranial magnetic stimulation and electroencephalography (TMS-EEG) biomarkers that would predict transcranial direct current stimulation (tDCS) response in obsessive-compulsive disorder with cathode electrode targeting orbitofrontal cortex (OFC). 30 OCD patients will be recruited to this study and performed once a day, five times a week direct current stimulation treatment for two weeks. The investigators will assess symptom severity before and after two weeks of tDCS. Through the study, Yale-Brown Obsessive Compulsive Scale（Y-BOCS）, the Obsessive Compulsive Inventory-Revised (OCI-R), the Beck Depression Inventory(BDI), Pittsburgh sleep quality index (PSQI)and side-effect questionnaire will be obtained by a trained investigator. Resting state electroencephalography and TMS-EEG testing will be conducted before and after tDCS treatment.

Connect with a study center

  • Shanghai Mental Health Center

    Shanghai, Shanghai 200030
    China

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.