Therapeutic Recommendations For The Treatment Of Children With A Retinoblastoma

Last updated: February 27, 2026
Sponsor: French Africa Pediatric Oncology Group
Overall Status: Active - Recruiting

Phase

N/A

Condition

Retinoblastoma

Treatment

OBSERVATIONAL

Clinical Study ID

NCT04425434
GFAOP RB1
  • Ages < 18
  • All Genders

Study Summary

As the survival of children with retinoblastoma in high income countries is higher than 95% including the bilateral forms this study hopes to improve the outcome in low income countries in Africa by improving early diagnosis and early implementation of this protocol of therapeutic recommendations for treatment.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Unilateral intraocular Retinoblastoma (RB)

  • Unilateral extraocular intraorbital (RB)

  • Bilateral intraocular (RB)

  • bilateral intraocular (RB) on one side and extraocular but intraorbital on the otherside.

Exclusion

Exclusion Criteria:

  • Externalized tumor mass

  • massive extension to optic nerve up to optical channeltumor

  • intracranial extension leptomeninges

  • cerebral parenchyma

  • extension to regional lymph nodes and/or remote metastases.

  • cerebrospinal fluid involvement.

  • Trilateral RB

  • Incapacity to followed the whole treatement.

Study Design

Total Participants: 3000
Treatment Group(s): 1
Primary Treatment: OBSERVATIONAL
Phase:
Study Start date:
November 01, 2020
Estimated Completion Date:
December 31, 2030

Study Description

In this study we will try to improve the outcome for children with stage II disease. It is hoped that we will be able to show that with early intervention correct early diagnosis the survival of these children is greatly improved. The collection of data in this observational study will allow us to show this improvement, by analysis of stage, treatment and outcome.

Connect with a study center

  • Hopital Yalgado Ouedraogo

    Ouagadougou, 03 BP 7022
    Burkina Faso

    Site Not Available

  • Hopital Yalgado Ouedraogo

    Ouagadougou 2357048, 03 BP 7022
    Burkina Faso

    Active - Recruiting

  • CUK (Cliniques Universitaires de Kinshasa)

    Kinshasa, BP 12 KIN XI
    Congo, The Democratic Republic of the

    Site Not Available

  • Cliniques Universitaires de Lubumbashi (CUL)

    Lubumbashi, BP 1825
    Congo, The Democratic Republic of the

    Site Not Available

  • CHU de Treichville à ABIDJAN

    Abidjan,
    Côte D'Ivoire

    Site Not Available

  • CHU de Treichville à ABIDJAN

    Abidjan 2293538,
    Côte d’Ivoire

    Active - Recruiting

  • CUK (Cliniques Universitaires de Kinshasa)

    Kinshasa 2314302, Kinshasa City 2314300 BP 12 KIN XI
    Democratic Republic of the Congo

    Active - Recruiting

  • Cliniques Universitaires de Lubumbashi (CUL)

    Lubumbashi 922704, BP 1825
    Democratic Republic of the Congo

    Active - Recruiting

  • HJRA, Hôpital universitaire Joseph Ravoahangy Andrianavalona

    Antananarivo, Ampefiloha BP 4150
    Madagascar

    Site Not Available

  • HJRA, Hôpital universitaire Joseph Ravoahangy Andrianavalona

    Antananarivo 1070940, Ampefiloha BP 4150
    Madagascar

    Active - Recruiting

  • CHU Gabriel Touré (HGT)

    Bamako,
    Mali

    Site Not Available

  • CHU Gabriel Touré (HGT)

    Bamako 2460596,
    Mali

    Active - Recruiting

  • Hôpital Aristide Le Dantec,

    Dakar, BP 3001
    Senegal

    Site Not Available

  • Hôpital Aristide Le Dantec,

    Dakar 2253354, BP 3001
    Senegal

    Active - Recruiting

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