QuadraMune(TM) for Prevention of COVID-19

Inclusion Criteria:

• Informed consent, provided electronically via the EDC, demonstrating the subjectunderstands the procedures required for the study and the purpose of the study Male orfemale patients 18 years of age or older that are considered to be high-riskindividuals.

• High-risk individuals are defined as all health care workers in hospitals, clinics,and emergency rooms, and medical facilities.

• Subjects must agree to practice at least two highly effective methods of birth controlfor the duration of the study This includes condoms with spermicide, oral birthcontrol pills, contraceptive implants, intra-uterine devices, or diaphragms. At leastone of these must be a barrier method. Subjects not of reproductive potential will beexempt (e.g. post-menopausal, surgically sterilized)

Exclusion Criteria:

• Refusal to provide informed consent Any previous positive test for COVID-19 by RT-PCRSymptomatic for COVID-19 Diarrhea prior to the start of treatment Type I or IIdiabetes Atherosclerotic Coronary Artery Disease Any contraindication for treatment with hydroxychloroquine including: Hypoglycemia G6PD deficiency Porphyria Anemia Neutropenia Alcoholism Myasthenia GravisSkeletal muscle disorder Maculopathy Changes in the visual field Liver disease, withALT/AST > 2.5 upper limit normal and total bilirubin >2.5 upper limit normal Psoriasis Anycomorbidities which, in the opinion of the investigator, constitute health risk for thesubject.