Multimodal Investigation of Intracranial Clot Environment

Last updated: May 27, 2024
Sponsor: University Hospital, Montpellier
Overall Status: Active - Recruiting

Phase

N/A

Condition

Stroke

Cerebral Ischemia

Occlusions

Treatment

Analysis of the clot

Clinical Study ID

NCT04421326
RECHMPL18_0236
  • Ages 18-100
  • All Genders

Study Summary

Analysis of peri clot blood collected at the acute phase of stroke in order to understand physiopathological mechanisms involved in the cerebrovascular damage

Eligibility Criteria

Inclusion

Inclusion criteria:

  1. Over 18 years of age,

  2. Non-dependent for activities of daily living prior to the onset of the MI (ModifiedRankin Score >2)

  3. Having an occlusion of a large arterial trunk proven by imaging (angio-MRI orangio-scanner).

Exclusion

Exclusion criteria:

  1. Patients initially admitted but for whom endovascular treatment will not finally beperformed (re-infusion, catheterization failure...) will be excluded from the study.

  2. Major patients under guardianship or curatorship or patients deprived of liberty

Study Design

Total Participants: 200
Treatment Group(s): 1
Primary Treatment: Analysis of the clot
Phase:
Study Start date:
March 14, 2021
Estimated Completion Date:
October 31, 2025

Study Description

It has been shown that immune cells accumulate around the clot at the acute phase of stroke. Leukocytes and their specific chemokines and cytokines regulation may impact cerebrovascular integrity.

Connect with a study center

  • University Hospital of Montpellier

    Montpellier,
    France

    Active - Recruiting

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