Physiological Changes of the Mitral Annulus After Annuloplasty in Barlow Disease

Last updated: August 2, 2021
Sponsor: University Hospital, Basel, Switzerland
Overall Status: Active - Recruiting

Phase

N/A

Condition

Mitral Valve Regurgitation

Treatment

N/A

Clinical Study ID

NCT04418960
2018-02240; ch20Grapow
  • Ages > 18
  • All Genders

Study Summary

Barlow disease (BD) is a common cause of mitral insufficiency. In 2012 the University Hospital of Basel started to perform a simplified mitral valve repair technique in BD just by implanting an annuloplasty-ring. It is hypothesized that the major mechanism of the valvular insufficiency in Barlow disease is a deformation of the left ventricle and the posterior mitral annulus, causing its aberrant displacement during the systole towards posterior and basal and thus impairing the coaptation of the leaflets. This prospective individual MRI study is to investigate the ventricle and the mitral annulus pre- and postoperatively for detailed analysis.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • identified Barlow disease suffering from significant mitral insufficiency withindication to surgery

Exclusion

Exclusion Criteria:

  • Active endocarditis or any other etiology of mitral insufficiency else than Barlowdisease
  • Inability to perform a cardiac MRI (e.g., metallic implants, claustrophobia)
  • Pregnancy
  • Inability to give consent

Study Design

Total Participants: 10
Study Start date:
September 21, 2018
Estimated Completion Date:
April 30, 2022

Connect with a study center

  • Cardiac Surgery, University Hospital Basel

    Basel, 4031
    Switzerland

    Active - Recruiting

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