EASiVENT Study Comparing INTELLiVENT-ASV vs Non Automated Ventilation in Adult ICU Patients

Inclusion Criteria:

• Weight greater than 40 kg

• Under invasive ventilation

• Expected to be mechanically ventilated after enrollment for at least 24 hours

• Agrees to not participate in other interventional research studies involvingmechanical ventilation for the duration of study

• Signature of the informed consent by the patient or his/her next-of-kin according tocountry or state regulation.

Exclusion Criteria:

• Fulfilling weaning criteria according to the weaning procedure of the ICU

• Need for "rescue therapy" (e.g: ECMO)

• Brain death status

• Respiratory drive disorder (Cheyne-Stokes breathing)

• Arterial hypoxia due to a non-pulmonary condition (right-to-left shunting due tocongenital disease, hepato-pulmonary syndrome, )

• Broncho-pleural fistula

• Chronic or acute dyshemoglobinemia: eg.: acute CO poisoning

• Chronic respiratory failure requiring long term invasive ventilation;

• Moribund patient

• Patient under guardianship, deprived of liberties

• Any other condition, that in the opinion of the IoR/designee, would precludeinformed consent (by the spouse/next of kin), make study participation unsafe,complicate interpretation of study outcome data, or otherwise interfere withachieving the study objectives.

• Low quality index on the SpO2 (Oxygen Saturation Measured by Pulse Oximetry)measurement

• Patients already enrolled in the present study in a previous episode of acuterespiratory failure

• High PaCO2 - ETCO2 gap (> 2.6 kPa or 19.5 mmHg) for > 3 hours

• Patient tracheostomized at the time of inclusion

• Patient ventilated with helium