Biomarkers of Acute Kidney Injury Following Cardiac Surgery

Last updated: May 8, 2020
Sponsor: University of Saskatchewan
Overall Status: Active - Recruiting

Phase

N/A

Condition

Kidney Failure

Kidney Disease

Renal Failure

Treatment

N/A

Clinical Study ID

NCT04387149
Bio 113
  • Ages 18-85
  • All Genders

Study Summary

Acute kidney injury occurs in up to 30% of patients undergoing cardiac surgery. Cardiac surgery associated-acute kidney injury (CSA-AKI) is characterized by a sudden and sustained decrease in renal function with insufficient elimination waste products. The problem is that postoperative diagnosis of CSA-AKI is delayed because it relies solely upon the slow and unreliable rise in serum creatinine (SCr) levels that may lead to delayed start in treatment and increased risk of adverse outcomes. We hypothesize that Matrix Metalloproteins (MMPs) -2, -9 and Neutrophil gelatinase-associated lipocalin (NGAL) are associated with and earlier detectors of CSA-AKI compared to levels of SCr.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • The inclusion criteria consisted of both sexes, 18-85 years of age, undergoingelective or urgent cardiac surgery with a hemoglobin (Hgb) >100 g/L.

Exclusion

Exclusion Criteria:

  • The exclusion criteria included were patients for emergent surgery, pre-existingchronic kidney disease (eGFR<30 mL/min) on dialysis or prescribed nephrotoxicmediations.

Study Design

Total Participants: 400
Study Start date:
January 06, 2020
Estimated Completion Date:
February 28, 2022

Study Description

Cardiopulmonary bypass (CPB), although essential to the performance of most cardiac operations, has been shown to cause injury to other organs, particularly to the kidneys and brain. Matrix Metalloproteins (MMPs) are ubiquitous proteolytic enzymes that degrade extracellular matrix and have been shown to be involved in injury to transplant kidneys. To date, no interventions are available to decrease the risk of cardiac surgery associated-acute kidney injury (CSA-AKI).

NGAL is a known indicator of injury to kidney, thus making it a promising biomarker for CSA-AKI. It may be that a single biomarker will not be sensitive and specific across the spectrum of CSA-AKI. This research investigates MMP-2, -9 and Neutrophil gelatinase-associated lipocalin (NGAL) and their association with and earlier detection of CSA-AKI compared to levels of SCr.

We hypothesize that increased activity of MMPs are associated with CSA-AKI. Furthermore, MMP-2 and/ or -9 may be predictors and/ or biomarkers for the early detection of CSA-AKI compared to serum levels of creatinine.

Connect with a study center

  • University of Saskatchewan

    Saskatoon, Saskatchewan S7N 0W8
    Canada

    Active - Recruiting

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