Peritransplant Ruxolitinib for Patients With Primary and Secondary Myelofibrosis

Inclusion Criteria:

• Age >= 18 years

• JAK INHIBITOR ADMINISTRATION INCLUSION: (PART I)

• Disease criteria:

• Diagnosis of primary myelofibrosis (PMF) as defined by the 2016 World HealthOrganization classification system or diagnosis of secondary myelofibrosis (MF)as defined by the International Working Group (IWG) for MyeloproliferativeNeoplasms Research and Treatment criteria

• Patients meeting the criteria for intermediate-1, intermediate-2 or high-riskdisease by Dynamic International Prognostic Scoring System (DIPSS) or DIPSSplus

• Ability to understand and the willingness to sign a written informed consentdocument

• Patient must be a potential hematopoietic stem cell transplant candidate as assessedby the consenting physician

• Patient must be willing to start ruxolitinib within a 6-month time period

• ALLOGENEIC STEM CELL TRANSPLANT INCLUSION: (PART II)

• Meeting criteria for part 1, as above, at time of initiation of ruxolitinib,including the ability to understand and willingness to sign a written informedconsent. Patients arriving to our institution for transplant and not enrolled inpart 1 may still be enrolled in part 2 if part 1 criteria are met. These patientswill have part 1 endpoints transcribed from medical records

• Received ruxolitinib for at least 8 weeks immediately prior to conditioning and bewilling to continue until 9-12 months post-transplant as tolerated

• Performance status score: Karnofsky >= 70

• Calculated creatinine clearance using the Cockcroft-Gault formula or 24 hour (hr)urine creatinine clearance must be > 60 ml/min

• Total serum bilirubin must be < 3 mg/dL unless the elevation is thought to be due toGilbert's disease or hemolysis

• Transaminases must be < 3 x the upper limit of normal

• Patients with clinical or laboratory evidence of liver disease will be evaluated forthe cause of liver disease, its clinical severity in terms of liver function, andthe degree of portal hypertension. Patients with fulminant liver failure, cirrhosiswith evidence of portal hypertension or bridging fibrosis, alcoholic hepatitis,hepatic encephalopathy, or correctable hepatic synthetic dysfunction evidenced byprolongation of the prothrombin time, ascites related to portal hypertension,bacterial or fungal abscess, biliary obstruction, chronic viral hepatitis with totalserum bilirubin > 3mg/dL, and symptomatic biliary disease will be excluded

• Diffusion capacity of lung for carbon monoxide (DLCO) corrected > 60% normal. May benot be on supplemental oxygen

• Left ventricular ejection fraction > 40% OR shortening fraction > 26%

• Comorbidity index < 5 at the time of pre-transplant evaluation

Exclusion Criteria:

• JAK INHIBITOR ADMINISTRATION EXCLUSION: (PART I)

• Contraindication to receiving ruxolitinib including:

• Patients who have known hypersensitivity to JAK inhibitors

• Clinical or laboratory evidence of significant renal or hepatic impairmentincluding cirrhosis

• Active uncontrolled infection

• Known human immunodeficiency virus (HIV) positivity

• Women who are pregnant or trying to conceive

• Caution should be used in patients with platelets < 100 though adjustments indose can be made to accommodate anyone with platelets > 50

• History of prior allogeneic transplant

• Leukemic transformation (> 20% blasts)

• ALLOGENEIC STEM CELL TRANSPLANT EXCLUSION: (PART II)

• Uncontrolled viral or bacterial infection at the time of transplant data review andconsent conference

• Active or recent (prior 6 month) invasive fungal infection without infectiousdisease (ID) consult and approval

• History of HIV infection

• Pregnant or breastfeeding

• Patients without a human leukocyte antigen (HLA)-identical sibling donor, 10 of 10HLA-matched or 9 of 10 allele mismatched unrelated donor, or umbilical cord bloodunits that meet transplant criteria