Home-based tDCS and Mindfulness-based Meditation for Self-management of Clinical Pain and Symptoms

Inclusion Criteria:

• have symptomatic knee OA based on American College of Rheumatology clinical criteria

• have had knee OA pain in the past 3 months with an average of at least 30 on a 0-100NRS for pain,

• can speak and read English

• have no plan to change medication regimens for pain throughout the trial

Exclusion Criteria:

• history of brain surgery, brain tumor, seizure, stroke, or intracranial metalimplantation

• systemic rheumatic disorders, including rheumatoid arthritis,systemic lupuserythematosus, and fibromyalgia

• alcohol/substance abuse

• diminished cognitive function that would interfere with understanding studyprocedures (i.e., Mini-Mental Status Exam score ≤ 23)

• pregnancy or lactation

• prosthetic knee replacement or non-arthroscopic surgery to the affected knee

• hospitalization within the preceding year for psychiatric illness

• no access to a device that can be used for secure videoconferencing for real-timeremote supervision.