Evaluation of Three Irrigants, Sodium Hypochlorite, Chlorhexidine and Combination of CHX+H2O2 in Endodontic Treatment.

Last updated: April 29, 2020
Sponsor: Postgraduate Institute of Dental Sciences Rohtak
Overall Status: Active - Recruiting

Phase

N/A

Condition

Periodontitis

Treatment

N/A

Clinical Study ID

NCT04373018
anshuyendo
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study will evaluate the synergistic effect of CHX + H2O2 when used as an irrigant during biomechanical preparation.in root canal treatment on periapical healing and compared with Chlorhexidine( CHX) and Sodium Hypochlorite (NaOCl).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • All patients over 18 years of age.

  • Mature permanent mandibular molars.

  • A radiographic evidence of periapical radiolucency (minimum size > 2mm×2mm) and a diagnosis of pulpal necrosis, as confirmed by the negative response to cold and electrical tests; and absence of bleeding on entering the pulp chamber.

Exclusion Criteria

  • Diabetics, immunocompromised patients, pregnant females, any systemic disease.

  • Patients with a history of analgesic intake within the past 3 days and antibiotics in the last month.

  • Patients with pockets ≥ 4mm or having marginal or furcal bone loss due to periodontitis.

  • Non-restorable tooth, fractured, perforated roots and inflammatory root resorption.

  • Teeth those are not suitable for rubber dam isolation.

  • Primary teeth.

Study Design

Total Participants: 90
Study Start date:
December 01, 2019
Estimated Completion Date:
April 30, 2021

Study Description

After a thorough history, clinical and radiographic examination with all eligibility confirmation, written informed consent will be taken from the patient after explaining the procedure and its associated risks and benefits. Patients randomly allocated to one of the three study groups Sodium hypochlorite (NaOCl), Chlorhexidine (CHX) and combination of (CHX+H2O2). All three irrigants will be used according to standard protocol during biomechanical preparation. Pain analysis will be carried out preoperatively and postoperatively at every 6 hours for 1 day and then every 24 hours till 7 days after the intervention. All the subjects will be followed up for evaluation of clinical and radiographic success at 3, 6 months and 1year.

Connect with a study center

  • PGIDS, Rohtak

    Rohtak, Haryana
    India

    Active - Recruiting

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